Evolution of ageing
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Summary
This work has shown that mortality may be due to an energy-saving strategy of reduced error regulation in somatic cells, which supports Orgel's ‘error catastrophe’ hypothesis and offers a new basis for the study of normal and abnormal ageing syndromes and of apparently immortal transformed cell lines.
- Type
- article
- Published
- 1977-11-24
- Cited by
- 1,887
- References
- 13
- OpenAlex
- https://openalex.org/W1993091967
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:492012
Keywords
Ageing, Somatic cell, Biology, Evolutionary biology, Genetics
References
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- On the origin of the genetic code and the stability of the translation apparatus.
- Kinetic proofreading: a new mechanism for reducing errors in biosynthetic processes requiring high specificity.
- The Selfish Gene
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- Alternate metabolism during the dauer stage of the nematode Caenorhabditis elegans.
- Spend less, live longer. The "thrifty aged" hypothesis.
- Cytoplasmic genomes that confer additionallongevity in Drosophila melanogaster
- Do large dogs die young?
- Bats and birds: Exceptional longevity despite high metabolic rates.
- Disease-Aging Network Reveals Significant Roles of Aging Genes in Connecting Genetic Diseases
- Phenotypic plasticity and longevity in plants and animals: cause and effect?
- A proposal in relation to a genetic control of lifespan in mammals.
- Age-specific Effects of Novel Mutations in Drosophila Melanogaster I. Mortality
- The heat dissipation limit theory and evolution of life histories in endotherms--time to dispose of the disposable soma theory?
- Biomarkers, interventions and healthy ageing.
- Gamma-Tocotrienol Modulated Gene Expression in Senescent Human Diploid Fibroblasts as Revealed by Microarray Analysis
- Investigating the role of the small Heat Shock Protein, HSP-12.6, in longevity in Caenorhabditis elegans
- Arterial Stiffening Provides Sufficient Explanation for Primary Hypertension
- Ant Colonies Do Not Trade-Off Reproduction against Maintenance
- Balanced intake of protein and carbohydrate maximizes lifetime reproductive success in the mealworm beetle, Tenebrio molitor (Coleoptera: Tenebrionidae).
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