Evidence for dynamically organized modularity in the yeast protein–protein interaction network
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Summary
This work investigated how hubs might contribute to robustness and other cellular properties for protein–protein interactions dynamically regulated both in time and in space, and uncovered two types of hub: ‘party’ hubs, which interact with most of their partners simultaneously, and ‘date’ Hubs, which bind their different partners at different times or locations.
- Type
- article
- Published
- 2004-07-01
- Cited by
- 1,809
- References
- 48
- OpenAlex
- https://openalex.org/W2012852001
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:4426721
Keywords
Interactome, Robustness (evolution), Modularity (biology), In silico, Computational biology
References
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Cited by
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- Protein function, connectivity, and duplicability in yeast.
- Insights from molecular investigations of traditional Chinese herbal stroke medicines: implications for neuroprotective epilepsy therapy.
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- Why Do Hubs in the Yeast Protein Interaction Network Tend To Be Essential: Reexamining the Connection between the Network Topology and Essentiality
- Visualization and orchestration of the dynamic molecular society in cells
- The analysis of the drug–targets based on the topological properties in the human protein–protein interaction network
- Disease-Aging Network Reveals Significant Roles of Aging Genes in Connecting Genetic Diseases
- Protein complex prediction based on simultaneous protein interaction network
- Protein–protein interaction networks and subnetworks in the biology of disease
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- BinTree Seeking: A Novel Approach to Mine Both Bi-Sparse and Cohesive Modules in Protein Interaction Networks
- Network motif comparison rationalizes Sec1/Munc18-SNARE regulation mechanism in exocytosis
- Toward a classification of isodynamic feed-forward motifs
- Counterbalance of ligand‐ and self‐coupled motions characterizes multispecificity of ubiquitin
- PAPTi: A Peptide Aptamer Interference Toolkit for Perturbation of Protein-Protein Interaction Networks
- A new method for predicting essential proteins based on dynamic network topology and complex information
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