Biological Functions of Autophagy Genes: A Disease Perspective
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Summary
The biological functions of autophagy genes are discussed from the perspective of understanding – and potentially reversing – the pathophysiology of human disease and aging.
- Type
- review
- Published
- 2019-01-01
- Cited by
- 2,514
- References
- 303
- Access
- Open access
- OpenAlex
- https://openalex.org/W2909477364
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:58657000
Keywords
Biology, Autophagy, Gene, Perspective (graphical), Disease
References
- Raptor/mTORC1 loss in adipocytes causes progressive lipodystrophy and fatty liver disease
- Increased autophagy blocks HER2-mediated breast tumorigenesis
- Aspirin Induces Lysosomal Biogenesis and Attenuates Amyloid Plaque Pathology in a Mouse Model of Alzheimer's Disease via PPARα
- Acetylation of Beclin 1 inhibits autophagosome maturation and promotes tumour growth
- The R740S mutation in the V‐ATPase a3 subunit results in osteoclast apoptosis and defective early‐stage autophagy
- Suppression of autophagy by FIP200 deletion leads to osteopenia in mice through the inhibition of osteoblast terminal differentiation
- Endogenous cardiac glycosides, a new class of steroid hormones.
- Endogenous Parkin Preserves Dopaminergic Substantia Nigral Neurons following Mitochondrial DNA Mutagenic Stress
- Beclin orthologs: integrative hubs of cell signaling, membrane trafficking, and physiology
- Accumulation of autophagic vacuoles and cardiomyopathy in LAMP-2-deficient mice
- Transcriptional control of autophagy–lysosome function drives pancreatic cancer metabolism
- Loss of Atg12, but not Atg5, in pro-opiomelanocortin neurons exacerbates diet-induced obesity
- Induction of autophagy and inhibition of tumorigenesis by beclin 1
- ATM Functions at the Peroxisome to Induce Pexophagy in Response to ROS
- Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism
- The autoimmunity-associated gene CLEC16A modulates thymic epithelial cell autophagy and alters T cell selection
- Mitophagy defects arising from BNip3 loss promote mammary tumor progression to metastasis
- AMPK activation of muscle autophagy prevents fasting-induced hypoglycemia and myopathy during aging.
- Translocation of interleukin-1β into a vesicle intermediate in autophagy-mediated secretion
- Autosis occurs in the liver of patients with severe anorexia nervosa
Cited by
- Electroacupuncture alleviates post-stroke cognitive impairment through inhibiting miR-135a-5p/mTOR/NLRP3 axis-mediated autophagy.
- Deficiency of Atg6 impairs beneficial effect of metformin on intestinal stem cell aging in Drosophila.
- Therapeutic modulation of autophagy: which disease comes first?
- Parkinsonisms and Glucocerebrosidase Deficiency: A Comprehensive Review for Molecular and Cellular Mechanism of Glucocerebrosidase Deficiency
- Autophagy in liver diseases: Time for translation?
- Defective proteostasis in celiac disease as a new therapeutic target
- The autophagic membrane tether ATG2A transfers lipids between membranes
- Autophagy suppresses the pathogenic immune response to dietary antigens in cystic fibrosis
- Novel insights into the clinical and molecular spectrum of congenital disorders of autophagy
- Mechanical Stress-Dependent Autophagy Component Release via Extracellular Nanovesicles in Tumor Cells.
- Deciphering the Rules of in Silico Autophagy Methods for Expediting Medicinal Research.
- Pharmacological Autophagy Regulators as Therapeutic Agents for Inflammatory Bowel Diseases.
- Autophagy: Supporting cellular and organismal homeostasis by self-eating.
- Stress – (self) eating: Epigenetic regulation of autophagy in response to psychological stress
- ATG8-binding UIM Proteins Define a New Class of Autophagy Adaptors and Receptors
- The molecular machinery of regulated cell death
- The Effects of Astragalus membranaceus Active Extracts on Autophagy-Related Diseases
- Signaling pathways involved in regulating apoptosis induction in host cells upon PRRSV infection
- Genistein antagonizes gliadin-induced CFTR malfunction in models of celiac disease
- Ferritinophagy is required for the induction of ferroptosis by the bromodomain protein BRD4 inhibitor (+)-JQ1 in cancer cells
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