Therapeutic modulation of autophagy: which disease comes first?
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Summary
The induction and inhibition of autophagy may provide new strategies for intervening on major and specific diseases, respectively, and the scheme provides an overview on pathologies that might be targeted by the manipulation of Autophagy.
- Type
- review
- Published
- 2019-02-06
- Cited by
- 61
- References
- 109
- Access
- Open access
- OpenAlex
- https://openalex.org/W2911751210
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:59606868
Keywords
Autophagy, Druggability, Disease, Biology, Medicine
References
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- The apoptosis/autophagy paradox: autophagic vacuolization before apoptotic death
- Cancer Immunoediting: Integrating Immunity’s Roles in Cancer Suppression and Promotion
- Pathogenic role of BECN1/Beclin 1 in the development of amyotrophic lateral sclerosis
- A dual role for autophagy in a murine model of lung cancer
- Essential role for autophagy in life span extension.
- Autophagy and aging.
- Immune Checkpoint Targeting in Cancer Therapy: Towards Combination Strategies with Curative Potential
- Redundant cell death mechanisms as relics and backups
- Anticancer chemotherapy-induced intratumoral recruitment and differentiation of antigen-presenting cells.
- Lysosomal Membrane Permeabilization Induces Cell Death in a Mitochondrion-dependent Fashion
- p53 status determines the role of autophagy in pancreatic tumour development
- Autophagy and Viruses: Adversaries or Allies?
Cited by
- Autophagy and cardiac aging
- The Effects of Astragalus membranaceus Active Extracts on Autophagy-Related Diseases
- Hormetic Effects of Phytochemicals on Health and Longevity.
- Fibrates as drugs with senolytic and autophagic activity for osteoarthritis therapy
- The role of airway myofibroblasts in asthma.
- Autophagy and Its Relationship to Epithelial to Mesenchymal Transition: When Autophagy Inhibition for Cancer Therapy Turns Counterproductive
- Molecular Mechanisms Underlying Autophagy-Mediated Treatment Resistance in Cancer
- Role of autophagy-related proteins and cellular microRNAs in chikungunya and dengue virus infection
- Inhibition of Transglutaminase 2 as a Potential Host-Directed Therapy Against Mycobacterium tuberculosis
- Autophagy regulation as a promising approach for improving cancer immunotherapy.
- Macrophage Signaling Pathways in Pulmonary Nontuberculous Mycobacteria Infections.
- Cytotoxic Property of Grias neuberthii Extract on Human Colon Cancer Cells: A Crucial Role of Autophagy
- Phanginin R Induces Cytoprotective Autophagy via JNK/c-Jun Signaling Pathway in Non-Small Cell Lung Cancer A549 Cells.
- GPAT4-Generated Saturated LPAs Induce Lipotoxicity through Inhibition of Autophagy by Abnormal Formation of Omegasomes
- Multiple Facets of Autophagy and the Emerging Role of Alkylphosphocholines as Autophagy Modulators
- Development of a pH-responsive polymersome inducing endoplasmic reticulum stress and autophagy blockade
- Natural Compounds and Autophagy: Allies Against Neurodegeneration
- The Polyphenol Pterostilbene Ameliorates the Myopathic Phenotype of Collagen VI Deficient Mice via Autophagy Induction
- Calcium-Sensing Receptor in Adipose Tissue: Possible Association with Obesity-Related Elevated Autophagy
- How immune‐cell fate and function are determined by metabolic pathway choice
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