AMPK activation of muscle autophagy prevents fasting-induced hypoglycemia and myopathy during aging.
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Summary
It is reported that fasting mice lacking skeletal muscle AMPK (AMPK-MKO) results in hypoglycemia and hyperketosis, establishing an essential requirement for skeletal Muscle AMPK-mediated autophagy in preserving blood glucose levels during prolonged fasting as well as maintaining muscle integrity and mitochondrial function during aging.
- Type
- article
- Published
- 2015-06-02
- Cited by
- 240
- References
- 37
- Access
- Open access
- OpenAlex
- https://openalex.org/W1935072652
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:1447191
Keywords
Autophagy, AMPK, AMP-activated protein kinase, Endocrinology, Mitophagy
References
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- Liver autophagy contributes to the maintenance of blood glucose and amino acid levels
Cited by
- Effects of rapid or slow body weight reduction on intramuscular protein degradation pathways during equivalent weight loss on rats.
- Identification and Small Molecule Inhibition of an Activating Transcription Factor 4 (ATF4)-dependent Pathway to Age-related Skeletal Muscle Weakness and Atrophy
- Protein breakdown in cancer cachexia.
- Muscle mitochondrial stress adaptation operates independently of endogenous FGF21 action
- Regulation of autophagy in human skeletal muscle: effects of exercise, exercise training and insulin stimulation
- Activation of autophagy by globular adiponectin is required for muscle differentiation.
- Liver kinase B1 inhibits the expression of inflammation-related genes postcontraction in skeletal muscle.
- AMP-activated protein kinase and its multifaceted regulation of hepatic metabolism
- Insulin resistance and sarcopenia: mechanistic links between common co-morbidities.
- Role of AMPK in regulation of LC3 lipidation as a marker of autophagy in skeletal muscle.
- Sex-specific alterations in glucose homeostasis and metabolic parameters during ageing of caspase-2-deficient mice
- Lack of Adipocyte AMPK Exacerbates Insulin Resistance and Hepatic Steatosis through Brown and Beige Adipose Tissue Function
- Chronic intermittent hypoxia induces cardiac hypertrophy by impairing autophagy through the adenosine 5'-monophosphate-activated protein kinase pathway.
- Autophagy, Inflammation and Immunity: A Troika Governing Cancer and Its Treatment
- The in vivo role of AMP-activated protein kinase in the metabolic function of brown and beige adipose tissue
- Myostatin inhibition therapy for insulin-deficient type 1 diabetes
- Salsalate (Salicylate) Uncouples Mitochondria, Improves Glucose Homeostasis, and Reduces Liver Lipids Independent of AMPK-β1
- Exercise, fasting, and mimetics: toward beneficial combinations?
- AMPK as a Pro-longevity Target.
- Autophagy, Metabolic Disease, and Pathogenesis of Heart Dysfunction.
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