Transcriptional control of autophagy–lysosome function drives pancreatic cancer metabolism
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Summary
The results identify the MiT/TFE proteins as master regulators of metabolic reprogramming in pancreatic cancer and demonstrate that transcriptional activation of clearance pathways converging on the lysosome is a novel hallmark of aggressive malignancy.
- Type
- article
- Published
- 2015-07-01
- Cited by
- 575
- References
- 47
- Access
- Open access
- OpenAlex
- https://openalex.org/W1678795445
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:90101380
Keywords
TFEB, Autophagy, Lysosome, Cell biology, BAG3
References
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- TFEB Links Autophagy to Lysosomal Biogenesis
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- Lysosomal disorders: from storage to cellular damage.
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- Nuclear import by Karyopherin-βs: recognition and inhibition
- Autophagy regulates lipid metabolism
- Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma
- Genomic analysis of the Microphthalmia locus and identification of the MITF-J/Mitf-J isoform.
- An approach to correlate tandem mass spectral data of peptides with amino acid sequences in a protein database
- Autophagy and Metabolism
- Network organization of the human autophagy system
- The Nutrient-Responsive Transcription Factor TFE3, Promotes Autophagy, Lysosomal Biogenesis, and Clearance of Cellular Debris
- p53 status determines the role of autophagy in pancreatic tumour development
- Importin 7 and exportin 1 link c-Myc and p53 to regulation of ribosomal biogenesis
- Nuclear pore complex composition: a new regulator of tissue-specific and developmental functions
- A Gene Network Regulating Lysosomal Biogenesis and Function
- Integral and Associated Lysosomal Membrane Proteins
Cited by
- The inhibition of lung cancer cell migration by AhR-regulated autophagy
- Lysosomal Biology in Cancer
- Transcriptional factor EB regulates macrophage polarization in the tumor microenvironment
- The Autophagy Lysosomal Pathway and Neurodegeneration
- Mitophagy defects arising from BNip3 loss promote mammary tumor progression to metastasis
- Autophagy: Surviving stress in pancreatic cancer
- Cancer’s fuel choice: new flavors for a picky eater
- Cysteine cathepsin proteases: regulators of cancer progression and therapeutic response
- Autophagy, Metabolism, and Cancer
- Lysosomal membrane permeabilization in cell death: new evidence and implications for health and disease
- Pan-Bcl-2 inhibitor Obatoclax is a potent late stage autophagy inhibitor in colorectal cancer cells independent of canonical autophagy signaling
- Targeting the lysosome in cancer
- Pancreatic Cancer Metabolism - Breaking it down to build it back up
- Macroautophagy is dispensable for growth of KRAS mutant tumors and chloroquine efficacy
- Obesity and Cancer: The Oil that Feeds the Flame.
- Pancreatic cancer: Current research and future directions.
- The awesome lysosome
- The Synthesis and Evaluations of the 68Ga-Lissamine Rhodamine B (LRB) as a New Radiotracer for Imaging Tumors by Positron Emission Tomography
- TFEB and TFE3 are novel components of the integrated stress response
- The Evolving, Multifaceted Roles of Autophagy in Cancer.
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