Deficiency of Atg6 impairs beneficial effect of metformin on intestinal stem cell aging in Drosophila.
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Summary
This study shows that knockdown of Atg6, a crucial autophagy-related factor, in ISC induces age-related phenotypes of ISC such as hyperproliferation, centrosome amplification, and DNA damage accumulation, and suggests that Atg 6 is required for the inhibitory effect of metformin on ISC aging, providing an intervention mechanism of metforming on adult stem cell aging.
- Type
- article
- Published
- 2018-03-25
- Cited by
- 31
- References
- 39
- OpenAlex
- https://openalex.org/W2792044930
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:4161847
Keywords
Metformin, Stem cell, Biology, Phenotype, Autophagy
References
- Metformin inhibits age-related centrosome amplification in Drosophila midgut stem cells through AKT/TOR pathway.
- Drosophila EGFR pathway coordinates stem cell proliferation and gut remodeling following infection
- JNK activity in somatic stem cells causes loss of tissue homeostasis in the aging Drosophila gut
- Metformin promotes autophagy and apoptosis in esophageal squamous cell carcinoma by downregulating Stat3 signaling
- Physiological functions of Atg6/Beclin 1: a unique autophagy-related protein
- mTOR regulation of autophagy
- Paraquat: model for oxidant-initiated toxicity.
- Autophagy in stem cells
- Age-related changes in Drosophila midgut are associated with PVF2, a PDGF/VEGF-like growth factor
- Gene expression systems in Drosophila: a synthesis of time and space.
- Drosophila is an inclusive model for human diseases, growth and development.
- Mechanism of metformin: inhibition of DNA damage and proliferative activity in Drosophila midgut stem cell.
- Age- and oxidative stress-induced DNA damage in Drosophila intestinal stem cells as marked by Gamma-H2AX.
- Increased centrosome amplification in aged stem cells of the Drosophila midgut.
- Characterization of Midgut Stem Cell– and Enteroblast-Specific Gal4 Lines in Drosophila
- Evidence that stem cells reside in the adult Drosophila midgut epithelium
- JNK protects Drosophila from oxidative stress by trancriptionally activating autophagy
- Multipotent Drosophila Intestinal Stem Cells Specify Daughter Cell Fates by Differential Notch Signaling
- Autophagic and tumour suppressor activity of a novel Beclin1-binding protein UVRAG
- Activation of AMPK by the Putative Dietary Restriction Mimetic Metformin Is Insufficient to Extend Lifespan in Drosophila
Cited by
- Stem cell rejuvenation and the role of autophagy in age retardation by caloric restriction: An update.
- Biological Functions of Autophagy Genes: A Disease Perspective
- Prospects of Pharmacological Interventions to Organismal Aging
- The role of autophagy in maintaining intestinal mucosal barrier
- Spermidine rescues the deregulated autophagic response to oxidative stress of osteoarthritic chondrocytes.
- Benefits of Metformin in Attenuating the Hallmarks of Aging
- A geroscience perspective on immune resilience and infectious diseases: a potential case for metformin
- Metformin-Induced MicroRNA-34a-3p Downregulation Alleviates Senescence in Human Dental Pulp Stem Cells by Targeting CAB39 through the AMPK/mTOR Signaling Pathway
- Metformin: A Potential Candidate for Targeting Aging Mechanisms
- How autophagy controls the intestinal epithelial barrier
- New Insight into the Effects of Metformin on Diabetic Retinopathy, Aging and Cancer: Nonapoptotic Cell Death, Immunosuppression, and Effects beyond the AMPK Pathway
- The Aged Intestine: Performance and Rejuvenation
- Metformin in aging and aging-related diseases: clinical applications and relevant mechanisms
- What we have learnt from Drosophila model organism: the coordination between insulin signaling pathway and tumor cells
- A bacteria-regulated gut peptide determines host dependence on specific bacteria to support host juvenile development and survival
- Metformin suppresses progression of muscle aging via activation of the AMP kinase-mediated pathways in Drosophila adults.
- Metformin promotes female germline stem cell proliferation by upregulating Gata-binding protein 2 with histone β-hydroxybutyrylation
- Modulation of stem cell fate in intestinal homeostasis, injury and repair
- The nonautophagic functions of autophagy-related proteins
- BECLIN1 is essential for intestinal homeostasis involving autophagy-independent mechanisms through its function in endocytic trafficking
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