Effects of an unusual poison identify a lifespan role for Topoisomerase 2 in Saccharomyces cerevisiae
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Summary
Evidence is presented supporting the hypothesis that an age-associated decay in genome maintenance promotes aging in Saccharomyces cerevisiae due to an inability to sense or repair DNA damage by topoisomerase 2 (yTop2), and intrinsic yTop2-mediated DNA damage is identified as a potentially manageable cause of aging.
- Type
- article
- Published
- 2017-01-01
- Cited by
- 12
- References
- 101
- Access
- Open access
- OpenAlex
- https://openalex.org/W2571143476
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:5609974
Keywords
Saccharomyces cerevisiae, White (mutation), Gerontology, Art, Philosophy
References
- Characterization of two genes required for the position‐effect control of yeast mating‐type genes.
- DNA damage and DNA replication stress in yeast models of aging.
- Intercalative antitumor drugs interfere with the breakage-reunion reaction of mammalian DNA topoisomerase II.
- In vitro mutagenesis and plasmid shuffling: from cloned gene to mutant yeast.
- Aging genomes: A necessary evil in the logic of life
- Zygotic Genome Activation Triggers Chromosome Damage and Checkpoint Signaling in C. elegans Primordial Germ Cells.
- Inducible overexpression, purification, and active site mapping of DNA topoisomerase II from the yeast Saccharomyces cerevisiae.
- Genome Integrity in Aging: Human Syndromes, Mouse Models, and Therapeutic Options.
- A major 125‐kd membrane glycoprotein of Saccharomyces cerevisiae is attached to the lipid bilayer through an inositol‐containing phospholipid.
- Yeast Replicator: a high-throughput multiplexed microfluidics platform for automated measurements of single-cell aging
- Hyperactivation of the silencing proteins, Sir2p and Sir3p, causes chromosome loss.
- A novel assay for replicative lifespan in Saccharomyces cerevisiae.
- High-throughput analysis of yeast replicative aging using a microfluidic system
- Extrachromosomal rDNA circles--a cause of aging in yeast.
- Single Cell Analysis of Yeast Replicative Aging Using a New Generation of Microfluidic Device
- Genomics and the mechanism of P-glycoprotein (ABCB1)
- Variation of the supercoils in closed circular DNA by binding of antibiotics and drugs: evidence for molecular models involving intercalation.
- Overexpression of Type I Topoisomerases Sensitizes Yeast Cells to DNA Damage*
- Rapid protein extraction from Saccharomyces cerevisiae
- The DNA cleavage reaction of topoisomerase II: wolf in sheep's clothing
Cited by
- Endogenous single-strand DNA breaks at RNA polymerase II promoters in Saccharomyces cerevisiae
- Structure Characterization and Action Mechanism of an Antiaging New Compound from Gastrodia elata Blume
- DNA Damage by an essential enzyme: A delicate balance act on the tightrope.
- A conserved SUMO-Ubiquitin pathway directed by RNF4/SLX5-SLX8 and PIAS4/SIZ1 drives proteasomal degradation of topoisomerase DNA-protein crosslinks
- Proteomics of long-lived mammals
- A conserved SUMO pathway repairs topoisomerase DNA-protein cross-links by engaging ubiquitin-mediated proteasomal degradation
- Origin, Regulation, and Fitness Effect of Chromosomal Rearrangements in the Yeast Saccharomyces cerevisiae
- Lifespan extending properties of Kalanchoe daigremontiana plant extracts in Saccharomyces cerevisiae
- Live while the DNA lasts. The role of autophagy in DNA loss and survival of diploid yeast cells during chronological aging
- Targeting TOP2B as a vulnerability in aging and aging-related diseases.
- Reduction of DNA Topoisomerase Top2 Reprograms the Epigenetic Landscape and Extends Health and Life Span Across Species
- Positive cardioprotective effects of Topoisomerase II poison, LS1, in doxorubicin treatment
- Reduction of DNA Topoisomerase Top2 reprograms the epigenetic landscape and extends health and life span across species
- Reduction of DNA Topoisomerase Top2 reprograms the epigenetic landscape and extends health and life span across species
- Reduction of DNA Topoisomerase Top2 reprograms the epigenetic landscape and extends health and life span across species
- Deletion of TOP2B promoter using CRISPR-Cas9 induces senescence in HEK 293T cells
- Edinburgh Research Explorer Endogenous single-strand DNA breaks at RNA polymerase II promoters in Saccharomyces cerevisiae
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