The DNA cleavage reaction of topoisomerase II: wolf in sheep's clothing
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Summary
The DNA cleavage/ligation reaction of topoisomerase II is the target for some of the most successful anticancer drugs currently in clinical use, however, this same reaction also is believed to trigger chromosomal translocations that are associated with specific types of leukemia.
- Type
- review
- Published
- 2008-11-28
- Cited by
- 445
- References
- 163
- Access
- Open access
- OpenAlex
- https://openalex.org/W1985550031
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:5721142
Keywords
Topoisomerase, Biology, DNA, Cleavage (geology), Ligation
References
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- Encyclopedia of biological chemistry
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- On the coupling between ATP usage and DNA transport by yeast DNA topoisomerase II.
- Role of topoisomerase II beta in the resistance of 9-OH-ellipticine-resistant Chinese hamster fibroblasts to topoisomerase II inhibitors.
- Inhibitory effects of the tyrosine kinase inhibitor genistein on mammalian DNA topoisomerase II.
- Involvement of nucleic acid synthesis in cell killing mechanisms of topoisomerase poisons.
Cited by
- DNA cleavage and opening reactions of human topoisomerase IIα are regulated via Mg2+-mediated dynamic bending of gate-DNA
- Reversal of DNA damage induced Topoisomerase 2 DNA–protein crosslinks by Tdp2
- Selection of DNA Cleavage Sites by Topoisomerase II Results from Enzyme-induced Flexibility of DNA
- Polyisoprenylated methylated protein methyl esterase as a putative drug target for androgen-insensitive prostate cancer
- Progression of chromosomal damage induced by etoposide in G2 phase in a DNA-PKcs-deficient context
- Curcumin-inspired cytotoxic 3,5-bis(arylmethylene)-1-(N-(ortho-substituted aryl)maleamoyl)-4-piperidones: A novel group of topoisomerase II alpha inhibitors.
- Recognition and repair of chemically heterogeneous structures at DNA ends
- Proteolytic Degradation of Topoisomerase II (Top2) Enables the Processing of Top2·DNA and Top2·RNA Covalent Complexes by Tyrosyl-DNA-Phosphodiesterase 2 (TDP2)* ♦
- Synthesis of 7-substituted fluoroquinolone derivatives containing triazolidine dione moiety and In Vitro evaluation of their cytotoxic effects
- Einfluss von Inhibitoren der DNA-Doppelstrangbruch-Reparatur auf die Zytostatika-Sensitivität von Tumorzellen
- DNA double-strand breaks with 5′ adducts are efficiently channeled to the DNA2-mediated resection pathway
- GENETIC EXCHANGES OF INTEINS BETWEEN PRASINOVIRUSES (PHYCODNAVIRIDAE)
- A role for topoisomerase II alpha in chromosome damage in human cell lines
- Dual Inhibitors Against Topoisomerases and Histone Deacetylases
- DNA damage induced by hydroquinone can be prevented by fungal detoxification
- Phytochemicals as Anticancer and Chemopreventive Topoisomerase II Poisons
- Topoisomerase IB-DNA Interactions: X Marks the Spot
- HU-331 is a catalytic inhibitor of topoisomerase IIα.
- Characterization of valproic acid-initiated homologous recombination.
- Use of Divalent Metal Ions in the DNA Cleavage Reaction of Human Type II Topoisomerases
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