Proteomics of long-lived mammals
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Summary
The naked mole rat (NMR) shows unique proteomic signatures that contribute to longevity by overcoming several hallmarks of aging and several longevity‐related proteins such as Cip1/p21, FOXO3, TOP2A, AKT1, RICTOR, INSR, and SIRT6 harbor posttranslational modification (PTM) sites that preferentially appear in either short‐ or long‐lived species.
- Type
- review
- Published
- 2019-11-18
- Cited by
- 10
- References
- 153
- Access
- Open access
- OpenAlex
- https://openalex.org/W2987723528
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:208143068
Keywords
Longevity, Biology, Proteomics, Metabolomics, Crosstalk
References
- Protein posttranslational modifications: the chemistry of proteome diversifications.
- Protein species and moonlighting proteins: Very small changes in a protein's covalent structure can change its biochemical function.
- SIRT6 Overexpression Improves Various Aspects of Mouse Healthspan
- Species comparison of liver proteomes reveals links to naked mole-rat longevity and human aging
- dbPTM in 2019: exploring disease association and cross-talk of post-translational modifications
- Global analysis of methionine oxidation provides a census of folding stabilities for the human proteome
- The utility of ETD mass spectrometry in proteomic analysis.
- Genome analysis reveals insights into physiology and longevity of the Brandt’s bat Myotis brandtii
- Organization of the Mammalian Metabolome according to Organ Function, Lineage Specialization, and Longevity
- Side chain specificity of ADP-ribosylation by a sirtuin
- SIRT6 stabilizes DNA-dependent Protein Kinase at chromatin for DNA double-strand break repair
- The Promise of Proteomics for the Study of ADP-ribosylation
- Acetyl coenzyme A: a central metabolite and second messenger.
- Proteoform: a single term describing protein complexity
- Metabolic clues to salubrious longevity in the brain of the longest‐lived rodent: the naked mole‐rat
- Kalign – an accurate and fast multiple sequence alignment algorithm
- Genome Integrity in Aging: Human Syndromes, Mouse Models, and Therapeutic Options.
- SnapShotSnapShot: ADP-Ribosylation Signaling
- NAD+ metabolism and the control of energy homeostasis - a balancing act between mitochondria and the nucleus
- Sirtuin Chemical Mechanisms
Cited by
- The Molecular Floodgates of Stress-Induced Senescence Reveal Translation, Signalling and Protein Activity Central to the Post-Mortem Proteome
- Translational control in the naked mole-rat as a model highly resistant to cancer.
- New Perspectives on Avian Models for Studies of Basic Aging Processes
- Sirtuin 6: linking longevity with genome and epigenome stability
- Potential Satellite Cell-Linked Biomarkers in Aging Skeletal Muscle Tissue: Proteomics and Proteogenomics to Monitor Sarcopenia
- TFIIH mutations can impact on translational fidelity of the ribosome
- Nurturing longevity through natural compounds: Where do we stand, and where do we go?
- MRG15 alternative splicing regulates CDK1 transcriptional activity in mouse cell senescence and myocardial regeneration
- Genetic insights from long-lived mammals: lessons for companion animal aging and health
- Exercise attenuates the hallmarks of aging: Novel perspectives
- Metabolomics of aging in primary fibroblasts from small and large breed dogs
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