DNA damage and DNA replication stress in yeast models of aging.
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Summary
The role of DNA damage DNA damage andDNA replication stress DNA replication stress in both replicative and chronological aging chronological aging in S. cerevisiae is discussed and the relevance of these findings to the emerging view that DNA damageDNA damage and DNA replication Stress are important components of the senescent state that occurs at early stages of cancer.
- Type
- review
- Published
- 2012-01-01
- Cited by
- 22
- References
- 75
- OpenAlex
- https://openalex.org/W1481706934
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:27699990
Keywords
Biology, Control of chromosome duplication, DNA replication, DNA damage, DNA re-replication
References
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- Histone genes, DNA replication, apoptosis and aging: What are the connections?
- 2-(4-chlorophenyl)benzo-1,4-quinone induced ROS-signaling inhibits proliferation in human non-malignant prostate epithelial cells
- DNA Damage-induced Reactive Oxygen Species (ROS) Stress Response in Saccharomyces cerevisiae
- Life Span of Individual Yeast Cells
- Manganese superoxide dismutase activity regulates transitions between quiescent and proliferative growth
- Mutants in the Saccharomyces cerevisiae RAS2 gene influence life span, cytoskeleton, and regulation of mitosis.
Cited by
- Extension of Saccharomyces paradoxus Chronological Lifespan by Retrotransposons in Certain Media Conditions Is Associated with Changes in Reactive Oxygen Species
- DNA replication stress-induced loss of reproductive capacity in S. cerevisiae and its inhibition by caloric restriction
- Ribosomal DNA and cellular senescence: new evidence supporting the connection between rDNA and aging.
- Oxidative Stress and Programmed Cell Death in Yeast
- Loss of Ubp3 increases silencing, decreases unequal recombination in rDNA, and shortens the replicative life span in Saccharomyces cerevisiae
- Molecular mechanisms linking the evolutionary conserved TORC1-Sch9 nutrient signalling branch to lifespan regulation in Saccharomyces cerevisiae.
- Stratification of Yeast Cells during Chronological Aging by Size Points to the Role of Trehalose in Cell Vitality
- The role of metal metabolism and heat shock protein genes on replicative lifespan of the budding yeast, Saccharomyces cerevisiae
- The short-lived African turquoise killifish: an emerging experimental model for ageing
- External and internal triggers of cell death in yeast
- Hydrogen peroxide induced loss of heterozygosity correlates with replicative lifespan and mitotic asymmetry in Saccharomyces cerevisiae
- Effects of an unusual poison identify a lifespan role for Topoisomerase 2 in Saccharomyces cerevisiae
- DNA repair and mutations during quiescence in yeast
- CTT1 overexpression increases the replicative lifespan of MMS-sensitive Saccharomyces cerevisiae deficient in KSP1.
- Inactivation of RAD52 and HDF1 DNA repair genes leads to premature chronological aging and cellular instability
- Membrane potential independent transport of NH3 in the absence of ammonium permeases in Saccharomyces cerevisiae
- UNDERSTANDING THE MECHANISM OF GENOMIC INSTABILITY DURING REPLICATIVE AGING IN BUDDING YEAST
- INFLUENCE OF X-RAY AND MICROWAVE RADIATION ON DEAMINATION OF PURINE NUCLEOTIDES IN YEAST CELLS CANDIDA GUILLIERMONDII NP-4
- High-resolution yeast quiescence profiling in human-like media reveals interacting influences of auxotrophy and nutrient availability
- High-resolution yeast quiescence profiling in human-like media reveals complex influences of auxotrophy and nutrient availability
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