SOX2 expression is associated with a cancer stem cell state and down-regulation of CDX2 in colorectal cancer
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Summary
It is indicated that SOX2 expression induces a cellular stem cell state in human CRC with a decreased expression of CDX2, and at least part of the prognostic importance of SoX2 is mediated throughCDX2 down-regulation.
- Type
- article
- Published
- 2016-07-13
- Cited by
- 98
- References
- 54
- Access
- Open access
- OpenAlex
- https://openalex.org/W2472105705
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:15038661
Keywords
CDX2, SOX2, Colorectal cancer, Cancer stem cell, Cancer research
References
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- SOX2 Expression and Prognostic Significance in Ovarian Carcinoma
- Reduced CDX2 Expression Predicts Poor Overall Survival in Patients with Colorectal Cancer
- An intestine-specific homeobox gene regulates proliferation and differentiation
- A homeodomain protein related to caudal regulates intestine-specific gene transcription
- Oct3/4 and Sox2 are significantly associated with an unfavorable clinical outcome in human esophageal squamous cell carcinoma.
- YAP1 REGULATES OCT4 ACTIVITY AND SOX2 EXPRESSION TO FACILITATE SELF-RENEWAL AND VASCULAR MIMICRY OF STEM-LIKE CELLS
- Loss of CDX2 expression is associated with poor prognosis in colorectal cancer patients.
- Cervical Cancer Cells with Positive Sox2 Expression Exhibit the Properties of Cancer Stem Cells
- Silencing SOX2 Induced Mesenchymal-Epithelial Transition and Its Expression Predicts Liver and Lymph Node Metastasis of CRC Patients
- Expression of the SRY-related HMG box protein SOX2 in human gastric carcinoma.
- Cancer stem cells--perspectives on current status and future directions: AACR Workshop on cancer stem cells.
- Loss of Cdx2 Expression in Primary Tumors and Lymph Node Metastases is Specific for Mismatch Repair-Deficiency in Colorectal Cancer
- Expression of CD133 correlates with differentiation of human colon cancer cells.
- The Hippo pathway and human cancer
- The role of CDX2 in intestinal homeostasis and inflammation.
- Sox2 antagonizes the Hippo pathway to maintain stemness in cancer cells
- Expression of Hippo Pathway in Colorectal Cancer
- Predictive value of Sox2 expression in transurethral resection specimens in patients with T1 bladder cancer
- Cancer stem cells: A contentious hypothesis now moving forward.
Cited by
- Withaferin A induces cell death and differentiation in multiple myeloma cancer stem cells.
- The dark side of SOX2: cancer - a comprehensive overview
- SOX4: Joining the Master Regulators of Epithelial-to-Mesenchymal Transition?
- Enrichment of Colorectal Cancer Stem Cells by Spheroidal Culture and Gene Expression Analysis of Selected ABC Transporters
- SOX2 Is a Marker for Stem-like Tumor Cells in Bladder Cancer
- Shrimp miR-S8 Suppresses the Stemness of Human Melanoma Stem-like Cells by Targeting the Transcription Factor YB-1.
- Homeobox protein CDX2 as a prognostic biomarker in solid malignancies: a meta-analysis
- The prognostic value of cancer stem-like cell markers SOX2 and CD133 in stage III colon cancer is modified by expression of the immune-related markers FoxP3, PD-L1 and CD3.
- Cancer Stem Cell–Suppressing Activity of Chrysotoxine, a Bibenzyl from Dendrobium pulchellum
- Regulation of Cancer Stem Cell Self-Renewal by HOXB9 Antagonizes Endoplasmic Reticulum Stress-Induced Melanoma Cell Apoptosis via the miR-765-FOXA2 Axis.
- Association of CDX2 Expression With Survival in Early Colorectal Cancer: A Systematic Review and Meta‐analysis
- TBX21 predicts prognosis of patients and drives cancer stem cell maintenance via the TBX21–IL-4 pathway in lung adenocarcinoma
- SOX in development and disease
- Application of induced pluripotency in cancer studies.
- The miR-371∼373 Cluster Represses Colon Cancer Initiation and Metastatic Colonization by Inhibiting the TGFBR2/ID1 Signaling Axis.
- Salvianolic acid B reverses multidrug resistance in nude mice bearing human colon cancer stem cells
- SOX2‐mediated upregulation of CD24 promotes adaptive resistance toward targeted therapy in melanoma
- The pluripotency network in colorectal cancer pathogenesis and prognosis: an update.
- Tumour suppressor properties of miR‐15a and its regulatory effects on BCL2 and SOX2 proteins in colorectal carcinomas
- Expression of microRNA-145, OCT4, and SOX2 in double primary endometrioid endometrial and ovarian carcinomas.
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