Regulation of Cancer Stem Cell Self-Renewal by HOXB9 Antagonizes Endoplasmic Reticulum Stress-Induced Melanoma Cell Apoptosis via the miR-765-FOXA2 Axis.
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Summary
The data showed that the HOXB9-dependent, microRNA-765-mediated FOXA2 pathway contributes to the survival of melanoma under ER stress by maintaining the properties of cancer stem cells.
- Type
- article
- Published
- 2018-07-01
- Cited by
- 43
- References
- 35
- Access
- Open access
- OpenAlex
- https://openalex.org/W2785381384
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:46785926
Keywords
Unfolded protein response, Endoplasmic reticulum, Carcinogenesis, Cancer research, microRNA
References
- IDH1, a CHOP and C/EBPβ-responsive gene under ER stress, sensitizes human melanoma cells to hypoxia-induced apoptosis.
- Adaptation to ER stress as a driver of malignancy and resistance to therapy in human melanoma
- FOXA2 functions as a suppressor of tumor metastasis by inhibition of epithelial-to-mesenchymal transition in human lung cancers
- Endoplasmic reticulum stress inhibits cell cycle progression via induction of p27 in melanoma cells.
- HOXB9, a gene overexpressed in breast cancer, promotes tumorigenicity and lung metastasis
- Expression of the stem cell markers nestin and CD133 on circulating melanoma cells.
- Focus on melanoma.
- A tumorigenic subpopulation with stem cell properties in melanomas.
- MicroRNA-149*, a p53-responsive microRNA, functions as an oncogenic regulator in human melanoma
- Human CD271-positive melanoma stem cells associated with metastasis establish tumor heterogeneity and long-term growth.
- Talimogene Laherparepvec Improves Durable Response Rate in Patients With Advanced Melanoma.
- Nivolumab versus chemotherapy in patients with advanced melanoma who progressed after anti-CTLA-4 treatment (CheckMate 037): a randomised, controlled, open-label, phase 3 trial.
- Targeting ER stress-induced autophagy overcomes BRAF inhibitor resistance in melanoma.
- ER-Stress-Induced Differentiation Sensitizes Colon Cancer Stem Cells to Chemotherapy.
- Up-regulation of Mcl-1 is critical for survival of human melanoma cells upon endoplasmic reticulum stress.
- IKKα Activation of NOTCH LinksTumorigenesis via FOXA2 Suppression
- Melanoma and the Unfolded Protein Response
- Mir-765 promotes cell proliferation by downregulating INPP4B expression in human hepatocellular carcinoma
- SOX2 expression is associated with a cancer stem cell state and down-regulation of CDX2 in colorectal cancer
- PCAF-mediated acetylation of transcriptional factor HOXB9 suppresses lung adenocarcinoma progression by targeting oncogenic protein JMJD6
Cited by
- MicroRNA-1469, a p53-responsive microRNA promotes Genistein induced apoptosis by targeting Mcl1 in human laryngeal cancer cells.
- Regulation of the adaptation to ER stress by KLF4 facilitates melanoma cell metastasis via upregulating NUCB2 expression
- KLF4, a miR-32-5p targeted gene, promotes cisplatin-induced apoptosis by upregulating BIK expression in prostate cancer
- HypoxamiRs Profiling Identify miR-765 as a Regulator of the Early Stages of Vasculogenic Mimicry in SKOV3 Ovarian Cancer Cells
- Identification and Characterisation of Alternative Splice Variants of Hoxb9 and Their Correlation with Melanogenesis in the Black-Boned Chicken
- GAS5, a FoxO1-actived long noncoding RNA, promotes propofol-induced oral squamous cell carcinoma apoptosis by regulating the miR-1297-GSK3β axis
- Therapeutically targeting head and neck squamous cell carcinoma through synergistic inhibition of LSD1 and JMJD3 by TCP and GSK-J1
- MEETING REPORT: THE 4TH ANNUAL MEETING OF THE CHINESE SOCIETY FOR INVESTIGATIVE DERMATOLOGY: Reflections on the Rise of Cutaneous Biology Research in China.
- MiR-765 functions as a tumour suppressor and eliminates lipids in clear cell renal cell carcinoma by downregulating PLP2
- MiR-3196, a p53-responsive microRNA, functions as a tumor suppressor in hepatocellular carcinoma by targeting FOXP4.
- Identification of key microRNAs of plasma extracellular vesicles and their diagnostic and prognostic significance in melanoma
- Shrimp miR-965 induced the human melanoma stem-like cell apoptosis and inhibited their stemness by disrupting the MCL-1-ER stress-XBP1 feedback loop in a cross-species manner
- Dual Effects of Non-Coding RNAs (ncRNAs) in Cancer Stem Cell Biology
- LncRNA FOXD3-AS1 knockdown protects against cerebral ischemia/reperfusion injury via miR-765/BCL2L13 axis.
- Interplay between endoplasmic reticulum stress and non-coding RNAs in cancer
- MicroRNAs at the Crossroad of the Dichotomic Pathway Cell Death vs. Stemness in Neural Somatic and Cancer Stem Cells: Implications and Therapeutic Strategies
- HOXB9 promotes laryngeal squamous cell carcinoma progression by upregulating MMP12
- Artesunate combined with verteporfin inhibits uveal melanoma by regulation of the MALAT1/yes-associated protein signaling pathway
- FOXA2 inhibits doxorubicin-induced apoptosis via transcriptionally activating HBP rate-limiting enzyme GFPT1 in HCC cells
- Identification of microRNA expression profiles of CD44+ ovarian cancer stem cells
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