Sox2 antagonizes the Hippo pathway to maintain stemness in cancer cells
Explore this paper's citation graph
Summary
It is shown that, in osteosarcomas, Sox2 activates YAP by directly repressing transcription of its upstream negative regulators Nf2 and WWC1, promoting cancer cell stemness.
- Type
- article
- Published
- 2015-04-02
- Cited by
- 239
- References
- 70
- Access
- Open access
- OpenAlex
- https://openalex.org/W2013935331
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:2934731
Keywords
Hippo signaling pathway, SOX2, Cancer research, Biology, Transcription factor
References
- Osteoblast proliferation or differentiation is regulated by relative strengths of opposing signaling pathways
- Heterogeneity in cancer: cancer stem cells versus clonal evolution.
- Hedgehog signaling induces osteosarcoma development through Yap1 and H19 overexpression
- A nude mouse model of human osteosarcoma lung metastases for evaluating new therapeutic strategies
- Cancer Stem Cells
- Mutation spectrum of the retinoblastoma gene in osteosarcomas.
- Spatial organization of Hippo signaling at the plasma membrane mediated by the tumor suppressor Merlin/NF2
- Harness the power: new insights into the inhibition of YAP/Yorkie.
- Sox2 is required to maintain cancer stem cells in a mouse model of high-grade oligodendroglioma.
- A Role for the Retinoblastoma Protein As a Regulator of Mouse Osteoblast Cell Adhesion: Implications for Osteogenesis and Osteosarcoma Formation
- Mst1/2 signalling to Yap: gatekeeper for liver size and tumour development
- Molecular insights into NF2/Merlin tumor suppressor function
- Metastatic osteosarcoma induced by inactivation of Rb and p53 in the osteoblast lineage
- Expression of Yes-Associated Protein, YAP, in Common Solid Tumors
- Cancer stem cells--perspectives on current status and future directions: AACR Workshop on cancer stem cells.
- Long live sox2: sox2 lasts a lifetime.
- The Hippo Signaling Pathway in Development and Cancer
- The multiple roles for Sox2 in stem cell maintenance and tumorigenesis
- Sox2+ adult stem/progenitor cells are important for tissue regeneration and survival of mice
- The cancer stem cell: premises, promises and challenges
Cited by
- TEAD1 mediates the oncogenic activities of Hippo-YAP1 signaling in osteosarcoma.
- Osteosarcoma Stem Cells Have Active Wnt/β‐catenin and Overexpress SOX2 and KLF4
- A Review: Molecular Aberrations within Hippo Signaling in Bone and Soft-Tissue Sarcomas
- Formation of Tumorspheres with Increased Stemness without External Mitogens in a Lung Cancer Model
- miR-450b-5p Suppresses Stemness and the Development of Chemoresistance by Targeting SOX2 in Colorectal Cancer
- The Notch pathway promotes the cancer stem cell characteristics of CD90+ cells in hepatocellular carcinoma
- Expression Analysis of the Hippo Cascade Indicates a Role in Pituitary Stem Cell Development
- FOXM1 in sarcoma: role in cell cycle, pluripotency genes and stem cell pathways
- The Ecology and Evolution of Cancer: The Ultra-Microevolutionary Process.
- The Regulatory Role of KIBRA and PTPN14 in Hippo Signaling and Beyond
- YAP/TAZ at the roots of cancer
- GPR133 Promotes Glioblastoma Growth in Hypoxia.
- The bad seed: Cancer stem cells in tumor development and resistance.
- SOX2 expression is associated with a cancer stem cell state and down-regulation of CDX2 in colorectal cancer
- PPARγ agonists promote differentiation of cancer stem cells by restraining YAP transcriptional activity
- Chemoresistance of Lung and Breast Cancer Cells Growing Under Prolonged Periods of Serum Starvation
- A directly negative interaction of miR-203 and ZEB2 modulates tumor stemness and chemotherapy resistance in nasopharyngeal carcinoma
- Targeting the Hippo Signaling Pathway for Tissue Regeneration and Cancer Therapy
- The roles of the Hippo pathway in cancer metastasis.
- Prognostic value of the Hippo pathway transcriptional coactivators YAP/TAZ and β1-integrin in conventional osteosarcoma
Related papers
- HIPPO signaling resolves embryonic cell fate conflicts during establishment of pluripotency in vivo
- Spheroid body-forming cells in the human gastric cancer cell line MKN-45 possess cancer stem cell properties
- Sox2, a stemness gene, regulates tumor‐initiating and drug‐resistant properties in CD133‐positive glioblastoma stem cells
- Regulation of the Hippo pathway transcription factor TEAD
- Induction of cells with prostate cancer stem-like properties from mouse induced pluripotent stem cells via conditioned medium.
- Reporters of Cancer Stem Cells as a Tool for Drug Discovery
- Stem cells within established cancer cell lines: an impact on in vitro experiments
- Abstract 4309: Isolation, expansion and molecular characterization of lung cancer stem cells from NSCLC cell lines
- Osteosarcoma Stem Cells Have Active Wnt/β‐catenin and Overexpress SOX2 and KLF4