Loss of Cdx2 Expression in Primary Tumors and Lymph Node Metastases is Specific for Mismatch Repair-Deficiency in Colorectal Cancer
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Summary
Loss of C dx2 is a sensitive and specific predictor of MMR-deficiency, but is not limited to these tumors, suggesting that events “upstream” of the development of microsatellite instability may impact Cdx2 expression.
- Type
- article
- Published
- 2013-10-11
- Cited by
- 40
- References
- 29
- Access
- Open access
- OpenAlex
- https://openalex.org/W1998340711
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:2502018
Keywords
MLH1, MSH2, Medicine, Microsatellite instability, CDX2
References
- Reduced CDX2 Expression Predicts Poor Overall Survival in Patients with Colorectal Cancer
- Use of multivariate analysis to suggest a new molecular classification of colorectal cancer
- CDX2 is a useful marker of intestinal-type differentiation: a tissue microarray-based study of 629 tumors from various sites.
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- The intestine-specific homeobox gene Cdx2 decreases mobility and antagonizes dissemination of colon cancer cells
- Effects of Homeodomain Protein CDX2 Expression on the Proliferation and Migration of Lovo Colon Cancer Cells
- Cdx2 controls expression of the protocadherin Mucdhl, an inhibitor of growth and β-catenin activity in colon cancer cells.
- The added value of PMS2 immunostaining in the diagnosis of hereditary nonpolyposis colorectal cancer
- Hyperplastic polyps and DNA microsatellite unstable cancers of the colorectum
- CDX2, a Highly Sensitive and Specific Marker of Adenocarcinomas of Intestinal Origin: An Immunohistochemical Survey of 476 Primary and Metastatic Carcinomas
- Molecular heterogeneity of colorectal cancer: Implications for cancer control.
- Expression of MUC2, MUC5AC, MUC5B, and MUC6 mucins in colorectal cancers and their association with the CpG island methylator phenotype
- Differential diagnostic and functional role of the multi-marker phenotype CDX2/CK20/CK7 in colorectal cancer stratified by mismatch repair status
- Clinicopathological and protein characterization of BRAF‐ and K‐RAS‐mutated colorectal cancer and implications for prognosis
- Up and downregulation of p16Ink4a expression in BRAF-mutated polyps/adenomas indicates a senescence barrier in the serrated route to colon cancer
- CpG island methylation in sporadic colorectal cancers and its relationship to microsatellite instability.
- Characterization of rectal, proximal and distal colon cancers based on clinicopathological, molecular and protein profiles.
- Relationship of CDX2 Loss with Molecular Features and Prognosis in Colorectal Cancer: Implications for Clinical and Pathology Practice
- Classification of colorectal cancer based on correlation of clinical, morphological and molecular features
- V600EBraf induces gastrointestinal crypt senescence and promotes tumour progression through enhanced CpG methylation of p16INK4a
Cited by
- Loss of CDX2 gene expression is associated with DNA repair proteins and is a crucial member of the Wnt signaling pathway in liver metastasis of colorectal cancer
- Atypical teratoid/ rhabdoid tumor, an immunohistochemical study of potential diagnostic and prognostic markers
- Loss of CDX2 expression is associated with poor prognosis in colorectal cancer patients.
- Towards a Molecular Classification of Colorectal Cancer
- CDX2 downregulation is associated with poor differentiation and MMR deficiency in colon cancer.
- The clinical perspectives of CDX2 expression in colorectal cancer: a qualitative systematic review.
- SOX2 expression is associated with a cancer stem cell state and down-regulation of CDX2 in colorectal cancer
- Towards a molecular classification of colorectal cancer
- Methylation of CDX2 as a Predictor in Poor Clinical Outcome of Patients with Colorectal Cancer
- Epigenetic Biomarkers in Colorectal Cancer
- Targeted CDX2 expression inhibits aggressive phenotypes of colon cancer cells in vitro and in vivo
- Prognostic significance of CDX2 immunoexpression in poorly differentiated clusters of colorectal carcinoma
- Association of CDX2 Expression With Survival in Early Colorectal Cancer: A Systematic Review and Meta‐analysis
- The prognostic impact of CDX2 correlates with the underlying mismatch repair status and BRAF mutational status but not with distant metastasis in colorectal cancer
- Prognostic impact of CDX2 in stage II colon cancer: results from two nationwide cohorts
- CDX2 in colorectal cancer is an independent prognostic factor and regulated by promoter methylation and histone deacetylation in tumors of the serrated pathway
- Architects meets Repairers: The interplay between homeobox genes and DNA repair.
- Validation of the International Tumor Budding Consensus Conference 2016 recommendations on tumor budding in stage I-IV colorectal cancer.
- Combination of CDX2 expression and T stage improves prognostic prediction of colorectal cancer
- Immunohistochemical expression of CDX2 gene in colorectal carcinoma
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