Recognition of single-stranded RNA viruses by Toll-like receptor 7.
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Summary
It is shown that TLR7 recognizes the single-stranded RNA viruses, vesicular stomatitis virus and influenza virus, and insights into the pathways used by the innate immune cells in the recognition of viral pathogens are provided.
- Type
- article
- Published
- 2004-04-13
- Cited by
- 1,990
- References
- 35
- Access
- Open access
- OpenAlex
- https://openalex.org/W2161208630
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:1180697
Keywords
TLR7, Vesicular stomatitis virus, Biology, Innate immune system, Pattern recognition receptor
References
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- Mouse type I IFN-producing cells are immature APCs with plasmacytoid morphology
- Recombinant vesicular stomatitis virus expressing respiratory syncytial virus (RSV) glycoproteins: RSV fusion protein can mediate infection and cell fusion.
- Small anti-viral compounds activate immune cells via the TLR7 MyD88–dependent signaling pathway
- Viral infection switches non-plasmacytoid dendritic cells into high interferon producers
- Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: Activation of Toll-like receptor 7
- Herpes simplex virus type 1 activates murine natural interferon-producing cells through toll-like receptor 9.
- Toll‐like receptor expression in murine DC subsets: lack of TLR7 expression by CD8α+ DC correlates with unresponsiveness to imidazoquinolines
- Vesicular stomatitis virus glycoprotein containing the entire green fluorescent protein on its cytoplasmic domain is incorporated efficiently into virus particles.
- Pathway of vesicular stomatitis virus entry leading to infection.
- High-throughput engineering of the mouse genome coupled with high-resolution expression analysis
- Innate immune recognition: mechanisms and pathways
- Identification of Lps2 as a key transducer of MyD88-independent TIR signalling
- Specialization and complementarity in microbial molecule recognition by human myeloid and plasmacytoid dendritic cells
- Heterogeneity of freshly isolated human tonsil dendritic cells demonstrated by intracellular markers, phagocytosis, and membrane dye transfer.
Cited by
- Estimation of the effective doses of nasal-inactivated influenza vaccine in humans from mouse-model experiments.
- Sensitization of CD8 T Cells During Acute Viral Infections Impacts Bystander and Latecomer CD8 T Cell Responses : A Dissertation
- Interferon gene regulation: not all roads lead to Tolls.
- Development of a mucosal vaccine for influenza viruses: preparation for a potential influenza pandemic
- Type I interferon during viral infections: multiple triggers for a multifunctional mediator.
- Infection of human dendritic cells with herpes simplex virus type 1 dramatically diminishes the mRNA levels of the prostaglandin E(2) receptors EP2 and EP4.
- Toll-like receptor signaling is impaired in dendritic cells from patients with X-linked agammaglobulinemia.
- Toll-like receptor 7-induced naive human B-cell differentiation and immunoglobulin production.
- Recognition of viral nucleic acids in innate immunity
- Respiratory Viral Infections in Infants: Causes, Clinical Symptoms, Virology, and Immunology
- Myd88-Dependent Toll-Like Receptor 7 Signaling Mediates Protection from Severe Ross River Virus-Induced Disease in Mice
- Type I interferon: the ever unfolding story.
- Experimental vaccines against potentially pandemic and highly pathogenic avian influenza viruses
- Preservation of Dendritic Cell Function during Vesicular Stomatitis Virus Infection Reflects both Intrinsic and Acquired Mechanisms of Resistance to Suppression of Host Gene Expression by Viral M Protein
- Innate immune viral recognition: relevance to CNS infections.
- Toll-like receptor 8 senses degradation products of single-stranded RNA
- Endogenous retroviruses and the immune system
- Broad-Spectrum Inhibition of Respiratory Virus Infection by MicroRNA Mimics Targeting p38 MAPK Signaling
- The Role of Flaviviral Proteins in the Induction of Innate Immunity.
- Lack of interferon response in animals to naked siRNAs
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