Cutting Edge: BCAP Promotes Lupus-like Disease and TLR-Mediated Type I IFN Induction in Plasmacytoid Dendritic Cells
Explore this paper's citation graph
Summary
A novel role is shown for BCAP in promoting TLR-induced IFN-α production in pDC and in systemic lupus erythematosus pathogenesis.
- Type
- article
- Published
- 2019-05-01
- Cited by
- 19
- References
- 37
- Access
- Open access
- OpenAlex
- https://openalex.org/W2931300620
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:91189166
Keywords
TLR7, TLR9, Plasmacytoid dendritic cell, Immunology, Systemic lupus erythematosus
References
- BCAP: the tyrosine kinase substrate that connects B cell receptor to phosphoinositide 3-kinase activation.
- DOCK2 and DOCK5 Act Additively in Neutrophils To Regulate Chemotaxis, Superoxide Production, and Extracellular Trap Formation
- Receptor Cross-Linking on Human Plasmacytoid Dendritic Cells Leads to the Regulation of IFN-α Production1
- The multifaceted biology of plasmacytoid dendritic cells
- IκB kinase-α is critical for interferon-α production induced by Toll-like receptors 7 and 9
- Requirement for DNA CpG Content in TLR9-dependent Dendritic Cell Activation Induced by DNA-containing Immune Complexes
- Plasmacytoid Dendritic Cell Ablation Impacts Early Interferon Responses and Antiviral NK and CD8+ T Cell Accrual
- Role for B-cell adapter for PI3K (BCAP) as a signaling adapter linking Toll-like receptors (TLRs) to serine/threonine kinases PI3K/Akt
- Involvement of DNA-PKcs in the IL-6 and IL-12 Response to CpG-ODN Is Mediated by Its Interaction with TRAF6 in Dendritic Cells
- Control of toll-like receptor 7 expression is essential to restrict autoimmunity and dendritic cell proliferation.
- Spontaneous mutation of the Dock2 gene in Irf5−/− mice complicates interpretation of type I interferon production and antibody responses
- Early, transient depletion of plasmacytoid dendritic cells ameliorates autoimmunity in a lupus model
- Contribution of BCAP to maintenance of mature B cells through c-Rel
- B-cell adaptor for PI3K (BCAP) negatively regulates Toll-like receptor signaling through activation of PI3K
- Interleukin-1beta induction of NFkappaB is partially regulated by H2O2-mediated activation of NFkappaB-inducing kinase.
- Type I interferon negatively controls plasmacytoid dendritic cell numbers in vivo
- Essential Immunoregulatory Role for BCAP in B Cell Development and Function
- Annular PIP3 accumulation controls actin architecture and modulates cytotoxicity at the immunological synapse
- Overexpression of TLR7 promotes cell-intrinsic expansion and autoantibody production by transitional T1 B cells
- RAGE is a nucleic acid receptor that promotes inflammatory responses to DNA
Cited by
- Signalling, sorting and scaffolding adaptors for Toll-like receptors
- Priming of the cGAS-STING-TBK1 Pathway Enhances LPS-Induced Release of Type I Interferons
- Self-DNA Sensing by cGAS-STING and TLR9 in Autoimmunity: Is the Cytoskeleton in Control?
- A narrative review: the role of DOCK2 in immune-related diseases, hematopoietic or vascular diseases and solid tumor
- Molecular mechanism of enhancing the immune effect of the Newcastle disease virus vaccine in broilers fed with Bacillus cereus PAS38.
- Rho GTPase signaling in rheumatic diseases
- The Critical Role of Toll-like Receptor-mediated Signaling in Cancer Immunotherapy
- PhIP-Seq Reveals Autoantibodies for Ubiquitously Expressed Antigens in Viral Myocarditis
- Insights from DOCK2 in cell function and pathophysiology
- PI3K–Akt pathway-independent PIK3AP1 identified as a replication inhibitor of the African swine fever virus based on iTRAQ proteomic analysis
- CpG ODN 2102 promotes antibacterial immune responses and enhances vaccine-induced protection in golden pompano (Trachinotusovatus).
- CpG ODN 1668 as TLR9 agonist mediates humpback grouper (Cromileptes altivelis) antibacterial immune responses.
- B cell adapter for PI 3-kinase (BCAP) coordinates antigen internalization and trafficking through the B cell receptor
- IRF5 Controls Plasma Cell Generation and Antibody Production via Distinct Mechanisms Depending on the Antigenic Trigger
- Divergent functions of TLRs in gastrointestinal (GI) cancer: Overview of their diagnostic, prognostic and therapeutic value.
- BCAP Is an Interferon-Stimulated Gene That Enhances Type I Interferon Activity in Response to Lipopolysaccharide
- Discovery, delineation, and therapeutic targeting of a hyper-translation pathway driving cytokine release syndrome
Related papers
- Signalling pathways leading to IFN‐α production in human plasmacytoid dendritic cell and the possible use of agonists or antagonists of TLR7 and TLR9 in clinical indications
- CD300A AND CD300C ON PLASMACYTOID DENDRITIC CELLS ARE DOWN-REGULATED BY TLR7 AND TLR9 LIGAND INDUCED TYPE I INTERFERON: 814
- OP0162 Toll-like Receptor 7-, but Not Toll-like Receptor 9-, Mediated Interferon-α Production from Plasmacytoid Dendritic Cells in Systemic Lupus Erythematosus
- BCAP promotes TLR-induced IFNα in plasmacytoid DC
- Necrotizing lymphadenitis may be induced by overexpression of Toll-like receptor7 (TLR7) caused by reduced TLR9 transport in plasmacytoid dendritic cells (PDCs)
- Enhanced IFN-α production is associated with increased TLR7 retention in the lysosomes of palasmacytoid dendritic cells in systemic lupus erythematosus
- BCAP promotes Lupus-like disease and regulates IFNα production in pDC
- Antiviral protein Viperin promotes Toll-like receptor 7- and Toll-like receptor 9-mediated type I interferon production in plasmacytoid dendritic cells.
- TLR7 stimulation in human plasmacytoid dendritic cells leads to the induction of early IFN-inducible genes in the absence of type I IFN.