Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases
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Summary
Treatments targeting basic mitochondrial processes, such as energy metabolism or free-radical generation, or specific interactions of disease-related proteins with mitochondria hold great promise in ageing-related neurodegenerative diseases.
- Type
- review
- Published
- 2006-10-19
- Cited by
- 6,291
- References
- 102
- OpenAlex
- https://openalex.org/W2152165298
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:4421515
Keywords
Neurodegeneration, Mitochondrion, Oxidative stress, Mitochondrial DNA, Disease
References
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- Increased Lipid Peroxidation Precedes Amyloid Plaque Formation in an Animal Model of Alzheimer Amyloidosis
- Mechanism of Toxicity in Rotenone Models of Parkinson's Disease
- Early mitochondrial calcium defects in Huntington's disease are a direct effect of polyglutamines
- Mitochondrial DNA deletions in human brain: regional variability and increase with advanced age
- Mice lacking alpha-synuclein are resistant to mitochondrial toxins.
- Familial multisystem degeneration with parkinsonism associated with the 11778 mitochondrial DNA mutation
- Chronic mitochondrial energy impairment produces selective striatal degeneration and abnormal choreiform movements in primates.
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- Análisis del papel protector de los polifenoles en enfermedades neurodegenerativas
- Phosphorescent Oxygen-Sensitive Probes
- The role of lactate dehydrogenase B in aerobic glycolysis-mediated resistance to AB toxicity
- Klotho and βKlotho.
- Pathways to neurodegeneration: mechanistic insights from GWAS in Alzheimer's disease, Parkinson's disease, and related disorders.
- Declining brain glucose metabolism in normal individuals with a maternal history of Alzheimer disease
- The Nrf2-ARE cytoprotective pathway in astrocytes
- Mitochondrial ubiquitin ligase MITOL ubiquitinates mutant SOD1 and attenuates mutant SOD1-induced reactive oxygen species generation.
- Mitochondrial protein Preli-like is required for development of dendritic arbors and prevents their regression in the Drosophila sensory nervous system
- Melatonin protects against Nickel‐induced neurotoxicity in vitro by reducing oxidative stress and maintaining mitochondrial function
- Toxic response caused by a misfolding variant of the mitochondrial protein short-chain acyl-CoA dehydrogenase
- ICV STZ induced impairment in memory and neuronal mitochondrial function: A protective role of nicotinic receptor.
- Neuroprotective effect of naringin, a dietary flavonoid against 3-nitropropionic acid-induced neuronal apoptosis.
- Brain superoxide anion formation in immature rats during seizures: protection by selected compounds.
- Estrogen Regulation of Mitochondrial Bioenergetics: Implications for Prevention of Alzheimer’s Disease
- Tau Protein: Function and Pathology
- Calcium transporters and their role in the development of neuronal disease and neuronal damage.
- Where killers meet--permeabilization of the outer mitochondrial membrane during apoptosis.
- Amelioration of neurodegenerative diseases by cell death-induced cytoplasmic delivery of humanin.
- Molecular mechanisms of neurodegeneration mediated by dysfunctional subcellular organelles in transmissible spongiform encephalopathies.
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