Tau Protein: Function and Pathology
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Summary
Findings supported the concept that amyloid toxicity is tau dependent and that blocking/reducing the pathological effects of tau may be protective against the harmful effects of amyloids pathology, a concept that has indeed proven feasibility in various studies.
- Type
- article
- Published
- 2012-08-15
- Cited by
- 13
- References
- 193
- Access
- Open access
- OpenAlex
- https://openalex.org/W22928147
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:11116113
Keywords
Pile, Settlement (finance), Geotechnical engineering, Load testing, Dynamic load testing
References
- Tau Dephosphorylation at Tau-1 Site Correlates with its Association to Cell Membrane
- Tauopathy in Drosophila: Neurodegeneration Without Neurofibrillary Tangles
- Temporal organisation of hibernation in wild-type and tau mutant Syrian hamsters
- Caspase Activation in the Alzheimer's Disease Brain: Tortuous and Torturous.
- Pathways of tau fibrillization.
- Drosophila as a model for human neurodegenerative disease.
- The Role of Caspase Cleavage of Tau in Alzheimer Disease Neuropathology
- Phosphorylation modulates the local conformation and self‐aggregation ability of a peptide from the fourth tau microtubule‐binding repeat
- Ubiquitin is Associated with Early Truncation of Tau Protein at Aspartic Acid421 during the Maturation of Neurofibrillary Tangles in Alzheimer's Disease
- Physiological regulation of tau phosphorylation during hibernation
- Microtubule-associated protein tau. Abnormal phosphorylation of a non-paired helical filament pool in Alzheimer disease.
- Free fatty acids stimulate the polymerization of tau and amyloid beta peptides. In vitro evidence for a common effector of pathogenesis in Alzheimer's disease.
- The microtubule-associated protein tau forms a triple-stranded left-hand helical polymer.
- Microtubule-associated protein tau. A component of Alzheimer paired helical filaments.
- Apoptotic effect of caspase-3 cleaved tau in hippocampal neurons and its potentiation by tau FTDP-mutation N279K
- Tau Aggregates and Tau Pathology
- PHOSPHORYLATED TAU: TOXIC, PROTECTIVE, OR NONE OF THE ABOVE
- CBP/p300 in cell growth, transformation, and development.
- Activation of caspase-3 in single neurons and autophagic granules of granulovacuolar degeneration in Alzheimer's disease. Evidence for apoptotic cell death.
- Chronic lithium treatment decreases mutant tau protein aggregation in a transgenic mouse model
Cited by
- The role of tau oligomers in the onset of Alzheimer's disease neuropathology.
- Selective suppression of the α isoform of p38 MAPK rescues late-stage tau pathology
- Identification of Alzheimer biomarkers by FTIR: a pilot study
- Misfolded proteins as a therapeutic target in Alzheimer's disease.
- Role of tau protein in Alzheimer's disease: The prime pathological player.
- The IDIP framework for assessing protein function and its application to the prion protein
- Carbohydrate and lipid metabolism in multiple sclerosis: Clinical implications for etiology, pathogenesis, diagnosis, prognosis, and therapy.
- Role of calcium dysregulation in Alzheimer's disease and its therapeutic implications
- Evaluation of Pathological Perspectives Related to Alzheimers Disease
- An Overview of Current Research on Alzheimers Disease
- Tau, Glial Fibrillary Acidic Protein, and Neurofilament Light Chain as Brain Protein Biomarkers in Cerebrospinal Fluid and Blood for Diagnosis of Neurobiological Diseases
- The New Perspective of Alzheimer's Disease Research: Mechanism and Therapeutic Strategy of Neuronal Senescence.
- Strengthen Alzheimer’s Awareness Through Biomusic
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