DJ-1, a novel regulator of the tumor suppressor PTEN.
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Summary
DJ-1 expression was increased compared to paired nonneoplastic lung tissue, and correlated positively with relapse incidence, and is thus a key negative regulator of PTEN that may be a useful prognostic marker for cancer.
- Type
- article
- Published
- 2005-03-01
- Cited by
- 566
- References
- 72
- Access
- Open access
- OpenAlex
- https://openalex.org/W15766664
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:22124036
Keywords
Humanities, Art
References
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- Clinical relevance of molecular markers in lung cancer.
- Crystal Structure of Human DJ-1, a Protein Associated with Early Onset Parkinson's Disease*
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- Proteins affecting rod photoreceptor differentiation in the murine retina: A proteomics approach with emphasis on mTOR
- Chaperone and anti‐chaperone: Two‐faced synuclein as stimulator of synaptic evolution
- Kinase signaling pathways as potential targets in the treatment of Parkinson’s disease
- Loss of the Parkinson's disease-linked gene DJ-1 perturbs mitochondrial dynamics.
- Loss of DJ-1 impairs antioxidant response by altered glutamine and serine metabolism.
- Expression of DJ-1 in Neurodegenerative Disorders.
- Effect of DJ-1 Downregulation on the Functions of the First Trimester Extravillous Trophoblasts
- The Interplay among PINK1/PARKIN/Dj-1 Network during Mitochondrial Quality Control in Cancer Biology: Protein Interaction Analysis
- Reactive oxygen species regulate activity-dependent neuronal plasticity in Drosophila
- 13 PTEN and PI3 Kinase Signaling in the Nervous System
- Identifying new biomarkers and potential therapeutic targets for breast cancer through the integration of human plasma proteomics: a Mendelian randomization study and colocalization analysis
- The role of protein aggregates in neuronal pathology: guilty, innocent, or just trying to help?
- Upregulated DJ-1 promotes renal tubular EMT by suppressing cytoplasmic PTEN expression and Akt activation
- Oxygen sensing: a common crossroad in cancer and neurodegeneration.
- Zebrafish as a Model for the Study of Parkinson’s Disease
- Proteomic analysis of cell models of ovarian cancer tumour suppression
- A PROTEOMIC ANALYSIS OF NEOPLASTIC PROGRESSION IN BREAST CANCER
- Global quantitative analysis of protein expression and phosphorylation status in the liver of the medaka fish (Oryzias latipes) exposed to microcystin-LR I. Balneation study.
- The role of PTEN in cardioprotection against ischaemia-reperfusion injury
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