Mice lacking alpha-synuclein are resistant to mitochondrial toxins.

Keywords

Alpha-synuclein, Biology, Alpha (finance), Neuroscience, Parkinson's disease

References

• Dopamine mediates striatal malonate toxicity via dopamine transporter‐dependent generation of reactive oxygen species and D2 but not D1 receptor activationXu Xia, Nicole Schmidt, Peter Teismann — 2001
• Kinetic Stabilization of the α-Synuclein Protofibril by a Dopamine-α-Synuclein AdductKelly A. Conway, Jean‐Christophe Rochet, Robert M. Bieganski — 2001
• The herbicide paraquat causes up-regulation and aggregation of alpha-synuclein in mice: paraquat and alpha-synuclein.Amy Manning-Bog, Alison L. McCormack, Jie Li — 2002
• Nuclear translocation and transcription regulation by the membrane-associated guanylate kinase CASK/LIN-2Yi‐Ping Hsueh, Ting‐Fang Wang, Fu‐Chia Yang — 2000
• Induction of α-Synuclein Aggregation by Intracellular Nitrative InsultEvgenia Paxinou, Qiping Chen, Marie Weisse — 2001
• The A53T alpha-synuclein mutation increases iron-dependent aggregation and toxicity.Natalie Ostrerova-Golts, Leonard Petrucelli, John Hardy — 2000
• Dopamine Modulates the Susceptibility of Striatal Neurons to 3-Nitropropionic Acid in the Rat Model of Huntington’s DiseaseDavid S. Reynolds, Rebecca J. Carter, A. Jennifer Morton — 1998
• Mice Deficient in Cellular Glutathione Peroxidase Show Increased Vulnerability to Malonate, 3-Nitropropionic Acid, and 1-Methyl-4-Phenyl-1,2,5,6-TetrahydropyridinePéter Klivènyi, Ole A. Andreassen, Robert J. Ferrante — 2000
• Behavioral and neurochemical effects of wild-type and mutated human alpha-synuclein in transgenic mice.Eric K. Richfield, Mona Thiruchelvam, Deborah A. Cory‐Slechta — 2002
• Alpha-synuclein and neurodegenerative diseasesMichel Goedert — 2001
• GluR1 Glutamate Receptor Subunit Is Regulated Differentially in the Primate Basal Ganglia Following Nigrostriatal Dopamine DenervationRanjita Betarbet, Richard H. Porter, J. Timothy Greenamyre — 2000
• A Drosophila model of Parkinson's diseaseMel Β. Feany, Welcome Bender — 2000
• Dopamine-dependent neurotoxicity of α-synuclein: A mechanism for selective neurodegeneration in Parkinson diseaseJin Xu, Shyan‐Yuan Kao, Frank J.S. Lee — 2002
• Reversal of motor impairments in parkinsonian rats by continuous intrastriatal delivery of l-dopa using rAAV-mediated gene transferDeniz Kirik, Biljana Georgievska, Corinna Bürger — 2002
• Mice lacking alpha-synuclein have an attenuated loss of striatal dopamine following prolonged chronic MPTP administration.Robert E. Drolet, Bahareh Behrouz, Keith J. Lookingland — 2004
• MPTP induces alpha‐synuclein aggregation in the substantia nigra of baboonsNeil W. Kowall, Philippe Hantraye, Emmanuel Brouillet — 2000
• 6-Hydroxydopamine injections into the nigrostriatal pathway attenuate striatal malonate and 3-nitropropionic acid lesions.William F. Maragos, Rebekah J. Jakel, Zhen Pang — 1998
• α-Synuclein phosphorylation controls neurotoxicity and inclusion formation in a Drosophila model of Parkinson diseaseLi Chen, Mel Β. Feany — 2005
• Creatine increase survival and delays motor symptoms in a transgenic animal model of Huntington's disease.Ole A. Andreassen, Alpaslan Dedeoglu, Robert J. Ferrante — 2001
• Proteasome Inhibition Alters Neural Mitochondrial Homeostasis and Mitochondria Turnover*Patrick G. Sullivan, Natasa Dragicevic, Jian-Hong Deng — 2004

Cited by

• Untersuchung des Expressionsmusters und der Neuropathologie konditionaler Mausmodelle des Morbus ParkinsonSilke Nuber — 2008
• Adult neurogenesis in Parkinson’s diseaseAna María Pita Grandal — 2012
• Interaction between Neuromelanin and Alpha-Synuclein in Parkinson’s DiseaseGeorge D. Kuh, Andrea C. McAleenan — 2015
• shRNA targeting α-synuclein prevents neurodegeneration in a Parkinson's disease model.Shawn Bloom, Brenda Sulick, Jennie Chin Hansen — 2015
• Mitochondrial importance in Alzheimer's, Huntington's and Parkinson's diseases.Sónia C. Correia, Renato X. Santos, George Perry — 2012
• Mécanismes moléculaires et de signalisation induits par le stress oxydatif dans des modèles in vivo de la maladie de Parkinson chez la drosophile : intoxication au paraquat et expression de l'α-synucléineMarlène Cassar — 2012
• PROTEOMIC ANALYSIS OF DOPAMINE OXIDATION INDUCED MODIFICATIONS TO MITOCHONDRIAL PROTEINS: IMPLICATIONS FOR PARKINSON'S DISEASEVan Laar, V. Steven — 2008
• Role of glutathione s-transferase pi in neuronal protection under oxidative stress and proteasome inhibition relevance to Parkinson’s diseaseA. N. Carvalho — 2012
• Mitochondrial Involvement in Neurodegeneration and AgingAlicia M. Pickrell — 2012
• Neurodegeneration in Parkinson's disease: genetics enlightens physiopathology.Olga Corti, Margot Fournier, Alexis Brice — 2009
• Ubiquitin-proteasome system dysfunction in experimental models of Parkinson's diseaseF. Sun — 2007
• Signal Transduction Pathways Modulated by the PD-causative Gene LRRK2Iria Carballo‐Carbajal — 2009
• Alpha-synuclein in the neurodegenerative mechanisms of Parkinson's disease and dementia with Lewy bodiesR. Musgrove — 2012
• Genetic mouse models of neurodegenerative diseases.Alžbeta Trančíková, David Ramonet, Darren J. Moore — 2011
• Redox imbalance in Parkinson's disease.Shankar J. Chinta, Julie K. Andersen — 2008
• Regional lysosomal malfunction underlies the selectivity of alpha-synuclein neurodegenerationKristen Malkus — 2011
• Over‐expression of alpha‐synuclein in the nervous system enhances axonal degeneration after peripheral nerve lesion in a transgenic mouse strainHeike Siebert, Philipp J. Kahle, M. Kramer — 2010
• Deletion of Herp facilitates degradation of cytosolic proteinsHikari Miura, Koji Hashida, Hirofumi Sudo — 2010
• Mitochondrial alterations in Parkinson’s disease: new cluesMiquel Vila, David Ramonet, Céline Perier — 2008
• Limelight on Alpha-Synuclein: Pathological and Mechanistic Implications in NeurodegenerationPauline Wales, Raquel Pinho, Diana F. Lázaro — 2013

Related papers

• Cloning and Characterization of Rat BAT3 cDNAToshinori Ozaki, Eiji Hanaoka, Masahiko Naka — 1999
• EFFECT OF THE NEMATODE PHASMARHABDITIS HERMAPHRODITA ON YOUNG STAGES OF THE PEST SLUG ARION LUSITANICUSB. Grimm — 2002
• HLA-B-associated transcript 3 (Bat3)/Scythe is essential for p300-mediated acetylation of p53.Toru Sasaki, Eugene Gan, Andrew Wakeham — 2007
• Anthoxanthum Mosaic VirusP. L. Catherall — 1970
• Ecological and evolutionary importance of neighbors in the grass Anthoxanthum odoratumGerrit A. J. Platenkamp, T. C. Foin — 1990
• European Sweet Vernal Grasses (Anthoxanthum: Poaceae, Pooideae, Aveneae): A Morphometric Taxonomical ApproachManuel Pimentel Pereira, Graciela Estévez‐Pérez, Elvira Sahuquillo — 2007
• Memoirs: The Structure and Biology of Schizoneura Lanigera, Hausmann or Woolly Aphis of the Apple Tree: Part I.--The Apterous Viviparous FemaleJ. Dswidson — 1913
• HSV-1 strain McKrae is more neuroinvasive than HSV-1 KOS after corneal or vaginal inoculation in miceHong Wang, David J. Davido, Lynda A. Morrison — 2013
• The evolutionary history of placodes: a molecular genetic investigation of the larvacean urochordate Oikopleura dioicaSusan Bassham, John H. Postlethwait — 2005
• Viral Pathogens and the Advantage of Sex in the Perennial Grass Anthoxanthum odoratum [and Discussion]Steven E. Kelley — 1994