β‐Amyloid inhibits integrated mitochondrial respiration and key enzyme activities
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Summary
It is concluded that β‐amyloid can directly disrupt mitochondrial function, inhibits key enzymes and may contribute to the deficiency of energy metabolism seen in Alzheimer's disease.
- Type
- article
- Published
- 2001-12-28
- Cited by
- 493
- References
- 58
- OpenAlex
- https://openalex.org/W1503983308
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:11284120
Keywords
Cytochrome c oxidase, Pyruvate dehydrogenase complex, Mitochondrion, Biochemistry, Amyloid beta
References
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- New evidence that the Alzheimer beta-amyloid peptide does not spontaneously form free radicals: an ESR study using a series of spin-traps.
- Regional glucose metabolic abnormalities are not the result of atrophy in Alzheimer's disease
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- Beta-amyloid neurotoxicity requires fibril formation and is inhibited by congo red.
- Amyloid β Peptides Do Not Form Peptide-derived Free Radicals Spontaneously, but Can Enhance Metal-catalyzed Oxidation of Hydroxylamines to Nitroxides*
- Brain Cytochrome Oxidase in Alzheimer's Disease
- Cytochrome oxidase deficiency in Alzheimer's disease
- Interaction of Peroxynitrite with Mitochondrial Cytochrome Oxidase
- The A beta peptide of Alzheimer's disease directly produces hydrogen peroxide through metal ion reduction.
Cited by
- Nitric oxide-induced mitochondrial dysfunction: implications for neurodegeneration.
- ETUDE DE L'AMPLIFICATION DE LA NEURODEGENERESCENCE EXCITOTOXIQUE PAR UNE DYSFONCTION MITOCHONDRIALE : IMPLICATIONS POUR LA MALADIE DE HUNTINGTON
- Biochemical Markers of Physical Exercise on Mild Cognitive Impairment and Dementia: Systematic Review and Perspectives
- Unfolded Protein Response and Macroautophagy in Alzheimer’s, Parkinson’s and Prion Diseases
- Amyloid beta resistance and the Warburg effect: Re-examining Alzheimer's disease
- Vieillissement olfactif chez la souris normale et chez la souris APP/PS1, modèle de la maladie d'Alzheimer : implications de la neurogenèse et du système noradrénergique
- The effects of catalase and kisspeptin overexpression on amyloid peptide toxicity
- Flavonoids and neuroprotection: biochemical and population-based analyses of potential neuroprotective factors related to dementia.
- La mutation PS1 : caractérisation phénotypique neurochimique et neuropathologique de souris transgéniques, modèles de la maladie d'Alzheimer
- Pathogenesis of Alzheimer’s disease
- Characterization of Mitochondrial Dysfunction in the 7PA2 Cell Model of Alzheimer's Disease
- A review on the cause-effect relationship between oxidative stress and toxic proteins in the pathogenesis of neurodegenerative diseases.
- The Dying of the Light: Mitochondrial Failure in Alzheimer's Disease
- Structural studies of heterogeneous amyloid species of lysozymes and de novo protein albebetin and their cytotoxicity
- Mitochondrial cholesterol in health and disease.
- Synergistic effects of β-amyloid and ceramide-induced insulin resistance on mitochondrial metabolism in neuronal cells.
- Amyloid precursor protein (APP) and copper homeostasis in the human neuroblastoma cell line SH-SY5Y
- Investigation of BACE1 as a stress-induced regulator of neuronal metabolism
- Interaction between Alzheimer's Aβ1-42 Peptide and DNA Detected by Surface Plasmon Resonance
- Mitochondrial genomic contribution to mitochondrial dysfunction in Alzheimer's disease
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