Instability and decay of the primary structure of DNA
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Summary
The spontaneous decay of DNA is likely to be a major factor in mutagenesis, carcinogenesis and ageing, and also sets limits for the recovery of DNA fragments from fossils.
- Type
- review
- Published
- 1993-04-22
- Cited by
- 5,687
- References
- 83
- OpenAlex
- https://openalex.org/W2134259738
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:4283694
Keywords
DNA, Mutagenesis, Genome instability, DNA methylation, Chemistry
References
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- Ancient DNA and the polymerase chain reaction. The emerging field of molecular archaeology.
- Role of uracil-DNA glycosylase in mutation avoidance by Streptococcus pneumoniae
- I will survive: protecting and repairing spore DNA
- Heat mutagenesis in bacteriophage T4: another walk down the transversion pathway
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- The spectrum of spontaneous mutations in a Saccharomyces cerevisiae uracil-DNA-glycosylase mutant limits the function of this enzyme to cytosine deamination repair
- Production of large amounts of hydrogen peroxide by human tumor cells.
- Generation of single-nucleotide repair patches following excision of uracil residues from DNA
- Cellular role of yeast Apn1 apurinic endonuclease/3'-diesterase: repair of oxidative and alkylation DNA damage and control of spontaneous mutation
- Increased spontaneous mutation and alkylation sensitivity of Escherichia coli strains lacking the ogt O6-methylguanine DNA repair methyltransferase
- Expression of the E.coli 3‐methyladenine DNA glycosylase I gene in mammalian cells reduces the toxic and mutagenic effects of methylating agents.
Cited by
- Nucleotide excision repair and its connection with cancer and ageing.
- Cell cycle regulation of DNA mismatch repair protein expression and activity at the H-ras oncogenic hot spot
- Decontamination techniques in ancient DNA analysis
- Structure-function analysis of human enzymes initiating nucleobase repair in DNA and RNA
- Genetic variation and human longevity.
- Functions of SUMO in the Maintenance of Genome Stability.
- Abasic Sites Stimulate Double-stranded DNA Cleavage Mediated by Topoisomerase II
- MODEL FOR THE RATIONALIZATION OF MAGNETIC FIELD EFFECTS IN VIVO. APPLICATION OF THE RADICAL‐PAIR MECHANISM TO BIOLOGICAL SYSTEMS
- Involvement of XRCC1 and DNA Ligase III Gene Products in DNA Base Excision Repair*
- Effects of smoking and aging on oxidative DNA damage of human lymphocytes.
- The influence of DNA glycosylases on spontaneous mutation.
- Human Thymine DNA Glycosylase Binds to Apurinic Sites in DNA but Is Displaced by Human Apurinic Endonuclease 1*
- A possible new role for the anti-ageing peptide carnosine
- The Interaction of DNA Mismatch Repair Proteins with Human Exonuclease I*
- Historical overview: Searching for replication help in all of the rec places
- Molecular paleontology
- Beyond Watson and Crick: DNA Methylation and Molecular Enzymology of DNA Methyltransferases
- Oxidative DNA base damage by the antitumor agent 3-amino-1,2,4-benzotriazine 1,4-dioxide (tirapazamine).
- Distribution patterns of postmortem damage in human mitochondrial DNA.
- Structural characterization of the Fpg family of DNA glycosylases.
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