Production of large amounts of hydrogen peroxide by human tumor cells.
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Summary
Constitutive generation of large amounts of reactive oxygen intermediates, if it occurs in vivo, might contribute to the ability of some tumors to mutate, inhibit antiproteases, injure local tissues, and therefore promote tumor heterogeneity, invasion, and metastasis.
- Type
- article
- Published
- 1991-02-01
- Cited by
- 2,497
- References
- 54
- OpenAlex
- https://openalex.org/W1809723326
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:11802142
Keywords
Biochemistry, Chemistry, Horseradish peroxidase, Reactive oxygen species, Catalase
References
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Cited by
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- Chemotactic activity of substances derived from antibody-loaded tumor cells on granulocytes.
- Virucidal effect of myeloperoxidase on human immunodeficiency virus type 1-infected T cells
- Determination of ascorbic acid by isotachophoresis with regard to its potential in neuroblastoma therapy.
- Changes in glutathione status and the antioxidant system in blood and in cancer cells associate with tumour growth in vivo.
- p53 interacts with the DNA mismatch repair system to modulate the cytotoxicity and mutagenicity of hydrogen peroxide.
- H2O2-dependent Activation of GCLC-ARE4 Reporter Occurs by Mitogen-activated Protein Kinase Pathways without Oxidation of Cellular Glutathione or Thioredoxin-1*
- Hydrogen peroxide mediates Rac1 activation of S6K1.
- Stimulation of mitochondrial activity by p43 overexpression induces human dermal fibroblast transformation.
- AIF suppresses chemical stress‐induced apoptosis and maintains the transformed state of tumor cells
- Calcitriol sensitizes colon cancer cells to H2O2-induced cytotoxicity while inhibiting caspase activation.
- Proteomics analysis of protein expression and specific protein oxidation in human papillomavirus transformed keratinocytes upon UVB irradiation
- Selenium: a double-edged sword for defense and offence in cancer
- Combating melanoma: the use of photodynamic therapy as a novel, adjuvant therapeutic tool.
- Role of TP53 Mutations in Vulvar Carcinomas
- Administration, distribution, metabolism and elimination of polymer therapeutics.
- Starvation-induced activation of ATM/Chk2/p53 signaling sensitizes cancer cells to cisplatin
- Antitumor effect of Japanese apricot extract (MK615) on human cancer cells in vitro and in vivo through a reactive oxygen species-dependent mechanism.
- Antitumorigenic Potential of Linalool Is Accompanied by Modulation of Oxidative Stress: An In Vivo Study in Sarcoma-180 Solid Tumor Model
- The cancer stem cell marker aldehyde dehydrogenase is required to maintain a drug-tolerant tumor cell subpopulation.
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