Structure-function analysis of human enzymes initiating nucleobase repair in DNA and RNA
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Summary
In humans, there are four known glycosylases that initiate repair of uracils in DNA, and these are UNG, TDG, SMUG1, and MBD4, which are proposed to be the main enzyme for this purpose.
- Type
- dissertation
- Published
- 2008-01-01
- Cited by
- 0
- References
- 209
- Access
- Open access
- OpenAlex
- https://openalex.org/W4603879
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:55750023
Keywords
DNA glycosylase, DNA repair, Nucleobase, Uracil-DNA glycosylase, DNA replication
References
- A specific mismatch repair event protects mammalian cells from loss of 5-methylcytosine.
- Hyperthermostable protein structure maintained by intra and inter-helix ion-pairs in archaeal O6-methylguanine-DNA methyltransferase.
- Molecular views of recombination proteins and their control
- Gene-targeted mice lacking the Ung uracil-DNA glycosylase develop B-cell lymphomas
- Lynch Syndrome Genes
- Respiratory symptoms, lung function, and bone mineral density in a comprehensive population study: The Nord-Trøndelag Health Study 1995-97, The Bronchial Obstruction in Nord-Trøndelag Study
- Epidemiological studies of microalbuminuria. The Nord-Trøndelag health study 1995-97 (HUNT2)
- Reproductive outcome in women with rheumatic disease : a population registry based study of the effects of inflammatory rheumatic disease and connective tissue disease on reproductive outcome in Norwegian women in 1967-1995.
- Unified catalytic mechanism for DNA glycosylases.
- Excision of cytosine and thymine from DNA by mutants of human uracil‐DNA glycosylase.
- The DNA-repair protein AlkB, EGL-9, and leprecan define new families of 2-oxoglutarate- and iron-dependent dioxygenases
- Uracil DNA-glycosylase. Purification and properties of this enzyme isolated from blast cells of acute myelocytic leukemia patients.
- The role of the iron-sulfur cluster in Escherichia coli endonuclease III. A resonance Raman study.
- Positional cloning of the gene for Nijmegen breakage syndrome
- Poly(ADP‐ribose) polymerase‐1 protects excessive DNA strand breaks from deterioration during repair in human cell extracts
- Properties of purified uracil-DNA glycosylase from calf thymus. An in vitro study using synthetic DNA-like substrates.
- Structural basis for recognition and repair of the endogenous mutagen 8-oxoguanine in DNA
- Crystal structure of a suicidal DNA repair protein: the Ada O6‐methylguanine‐DNA methyltransferase from E. coli.
- Phylogenomic identification of five new human homologs of the DNA repair enzyme AlkB
- Crystal structure of a G:T/U mismatch-specific DNA glycosylase: mismatch recognition by complementary-strand interactions.
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