Oncogene-induced senescence relayed by an interleukin-dependent inflammatory network.
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Summary
A model is proposed in which the context-dependent cytostatic and promitogenic functions of specific interleukins contribute to connect senescence with an inflammatory phenotype and cancer.
- Type
- article
- Published
- 2008-06-13
- Cited by
- 2,016
- References
- 56
- Access
- Open access
- OpenAlex
- https://openalex.org/W2131078803
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:15295092
Keywords
Biology, Senescence, Oncogene, Interleukin, Cancer research
References
- Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence.
- Interleukin-6: possible implications in human diseases
- Development of a human interleukin-6 receptor antagonist.
- Molecular signature of oncogenic ras-induced senescence
- A functional screen identifies hDRIL1 as an oncogene that rescues RAS-induced senescence
- Plasminogen activator inhibitor-1 is a critical downstream target of p53 in the induction of replicative senescence
- ARF functions as a melanoma tumor suppressor by inducing p53-independent senescence
- Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis
- Senescent fibroblasts promote epithelial cell growth and tumorigenesis: A link between cancer and aging
- Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas
- C/EBPbeta at the core of the TGFbeta cytostatic response and its evasion in metastatic breast cancer cells.
- Intrinsic tumour suppression
- Replicative senescence of activated human hepatic stellate cells is accompanied by a pronounced inflammatory but less fibrogenic phenotype
- Downregulation of Wnt signaling is a trigger for formation of facultative heterochromatin and onset of cell senescence in primary human cells.
- Interleukin-6 Regulation of the Human DNA Methyltransferase (HDNMT) Gene in Human Erythroleukemia Cells*
- Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors.
- p15Ink4b is a critical tumour suppressor in the absence of p16Ink4a
- Acute mutation of retinoblastoma gene function is sufficient for cell cycle re-entry
- Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints
- Remodeling of chromatin structure in senescent cells and its potential impact on tumor suppression and aging.
Cited by
- Development of an shRNA screen to identify mediators of cellular senescence in human breast epithelial cells
- Multidrug resistance in cancer.
- Transcriptional regulation of cellular senescence
- Senescence and pre-malignancy: how do tumors progress?
- Cellular and molecular specificity of pituitary gland physiology.
- A role for c-Abl in cell senescence and spontaneous immortalization
- Wnt Antagonist SFRP1 Functions as a Secreted Mediator of Senescence
- Dissecting the telomere-independent pathways underlying human cellular senescence
- Loss of HuR leads to senescence-like cytokine induction in rodent fibroblasts by activating NF-κB.
- Tumor Dormancy, Oncogene Addiction, Cellular Senescence and Self-Renewal Programs
- Stromal-initiated changes in the bone promote metastatic niche development
- Meta-analysis of interleukin 6, 8, and 10 between off-pump and on-pump coronary artery bypass groups.
- The hepatic microenvironment essentially determines tumor cell dormancy and metastatic outgrowth of pancreatic ductal adenocarcinoma
- Sarcopenia: Aging-Related Loss of Muscle Mass and Function.
- Senolytic agent Quercetin ameliorates intervertebral disc degeneration via the Nrf2/NF-κB axis.
- Impact of physical activity on immune function and inflammation in the elderly
- Understanding the roles of Non-homologous end joining and p53 after DNA damage
- Oncogene-induced Cellular Senescence
- The role of human cytomegalovirus encoded viral G protein-coupled receptors in onco-modulatory signalling
- What determines the switch between atrophic and neovascular forms of age related macular degeneration? - the role of BMP4 induced senescence
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