Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors.

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Summary

The senescence response may be antagonistically pleiotropic, promoting early-life survival by curtailing the development of cancer but eventually limiting longevity as dysfunctional senescent cells accumulate.

Type
review
Published
2005-02-25
Cited by
2,346
References
116
Access
Open access

Keywords

Biology, Cell biology, Evolutionary biology

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