Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors.
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Summary
The senescence response may be antagonistically pleiotropic, promoting early-life survival by curtailing the development of cancer but eventually limiting longevity as dysfunctional senescent cells accumulate.
- Type
- review
- Published
- 2005-02-25
- Cited by
- 2,346
- References
- 116
- Access
- Open access
- OpenAlex
- https://openalex.org/W2024209230
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:9559146
Keywords
Biology, Cell biology, Evolutionary biology
References
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- The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus
- Mitochondrial oxidative stress causes chromosomal instability of mouse embryonic fibroblasts
- PML regulates p53 acetylation and premature senescence induced by oncogenic Ras
- Hayflick, his limit, and cellular ageing
- Regulation of cellular senescence by p53.
- Atmospheric carbon dioxide concentrations over the past 60 million years
- Normal human mammary epithelial cells spontaneously escape senescence and acquire genomic changes
- Cellular lifespan and senescence signaling in embryonic stem cells
- Why do we age?
- Tumor cell senescence in cancer treatment.
- A DNA damage checkpoint response in telomere-initiated senescence
- DNA damage foci at dysfunctional telomeres.
- Cellular senescence and apoptosis: how cellular responses might influence aging phenotypes.
- Longevity, stress response, and cancer in aging telomerase-deficient mice.
- Tumor suppressors and oncogenes in cellular senescence.
- Increased p16 expression with first senescence arrest in human mammary epithelial cells and extended growth capacity with p16 inactivation
- Tumor suppression by Ink4a-Arf: progress and puzzles.
Cited by
- Targeting the heat shock response in cancer: tipping the balance in transformed cells.
- Nucleotide excision repair and its connection with cancer and ageing.
- Molecular evolution of the p53 network in reptiles
- Senescence of Hematopoietic Stem Cells and Bone Marrow Failure
- p63: A New Link Between Senescence and Aging
- Heat shock proteins in cancer: chaperones of tumorigenesis.
- Ageing: Balancing regeneration and cancer
- Insights into degenerative aortic valve disease.
- Telomere dysfunction and stem cell ageing.
- High NaCl Promotes Cellular Senescence
- Bromodeoxyuridine inhibits cancer cell proliferation in vitro and in vivo.
- Mutation, replicative infidelity of DNA and aneuploidy sequentially in the formation of malignant pleomorphic tumors.
- Supportive care in elderly cancer patients
- Senescence and life span
- Metabolic syndrome is a real disease and premalignant state induced by oncogenic stresses to block malignant transformation.
- On the traces of XPD: cell cycle matters - untangling the genotype-phenotype relationship of XPD mutations
- Senescence and pre-malignancy: how do tumors progress?
- CLCA2 as a p53-inducible senescence mediator.
- An aging program at the systems level?
- Bexarotene Induces Cellular Senescence in MMTV-Neu Mouse Model of Mammary Carcinogenesis
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