Interleukin-6 Regulation of the Human DNA Methyltransferase (HDNMT) Gene in Human Erythroleukemia Cells*
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Summary
The data suggest that inflammatory cytokines such as IL-6 may exert many epigenetic changes in cells via the regulation of the methyltransferase gene, and may in fact be reflected in part by their ability to regulate the methylation of cellular genes.
- Type
- article
- Published
- 2001-10-26
- Cited by
- 165
- References
- 34
- Access
- Open access
- OpenAlex
- https://openalex.org/W2023688724
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:24787909
Keywords
DNA methyltransferase, Epigenetics, DNA methylation, Methyltransferase, Promoter
References
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- DNMT1 forms a complex with Rb, E2F1 and HDAC1 and represses transcription from E2F-responsive promoters
- Abnormal regulation of DNA methyltransferase expression during colorectal carcinogenesis.
- Extensive DNA methylation spanning the Rb promoter in retinoblastoma tumors.
- Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex
- Identification of a novel interleukin-6 response element containing an Ets-binding site and a CRE-like site in the junB promoter
- Monocyte-derived human B-cell growth factor identified as interferon-beta 2 (BSF-2, IL-6).
- Transcriptional regulation of the human DNA Methyltransferase (dnmt1) gene.
- Methylation patterns of immunoglobulin genes in lymphoid cells: correlation of expression and differentiation with undermethylation.
- Two major forms of DNA (cytosine-5) methyltransferase in human somatic tissues.
- Purification, sequence, and cellular localization of a novel chromosomal protein that binds to methylated DNA.
- Characterization of MeCP2, a vertebrate DNA binding protein with affinity for methylated DNA.
- Globin Gene Silencing in Primary Erythroid Cultures
- Role of DNA 5-methylcytosine transferase in cell transformation by fos.
- Circulating IL‐6‐type cytokines and sIL‐6R in patients with multiple myeloma
- In situ detection of the hypermethylation-induced inactivation of the p16 gene as an early event in oncogenesis.
- Gene methylation of oestrogen and epidermal growth factor receptors in neoplastic and perineoplastic breast tissues.
Cited by
- Elevated risk of colorectal adenoma with Helicobacter pylori‐related chronic gastritis: A population‐based case‐control study
- Interleukin 6 supports the maintenance of p53 tumor suppressor gene promoter methylation.
- Do all roads lead to Rome? The role of neuro-immune interactions before birth in the programming of offspring obesity
- Depression, Cytokine, and Cytokine by Treatment Interactions Modulate Gene Expression in Antipsychotic Naïve First Episode Psychosis
- Methylated oligonucleotide (MON)-induced promoter hypermethylation is associated with repression of CDH1 expression and contributes to the migration and invasion of human trophoblast cell lines.
- Dynamic changes in dna methylation status in peripheral blood Mononuclear cells following an acute bout of exercise: Potential impact of exercise-induced elevations in interleukin-6 concentration.
- High Incidence of MGMT and RARβ Promoter Methylation in Primary Glioblastomas: Association with Histopathological Characteristics, Inflammatory Mediators and Clinical Outcome
- Genetic and epigenetic changes associated with cholangiocarcinoma: from DNA methylation to microRNAs.
- Life after death: targeting high mobility group box 1 in emergent cancer therapies.
- Exercise and inflammation-related epigenetic modifications: focus on DNA methylation.
- Chronic Inflammation of the Oral Cavity and Squamous Cell DNA Methylation
- Epigenetic modification as an enabling mechanism for leukemic transformation.
- Sex differences in prenatal epigenetic programing of stress pathways
- lnflammation-induced epigenetic switches in cancer
- Influence of IL1B polymorphism on CpG island hypermethylation in Helicobacter pylori-infected gastric cancer
- Epigenetic regulation of E-cadherin controls endometrial receptivity.
- Epigenetic regulation of microRNA-370 by interleukin-6 in malignant human cholangiocytes
- A role for epigenetics in psoriasis: methylated Cytosine-Guanine sites differentiate lesional from nonlesional skin and from normal skin.
- DNMT3A and DNMT3B mediate autocrine hGH repression of plakoglobin gene transcription and consequent phenotypic conversion of mammary carcinoma cells
- The Epigenomic Viewpoint on Cellular Differentiation of Myeloid Progenitor Cells as it Pertains to Leukemogenesis
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