The role of senescent cells in ageing
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Summary
A deeper understanding of the molecular mechanisms underlying the multi-step progression of senescence and the development and function of acute versus chronic senescent cells may lead to new therapeutic strategies for age-related pathologies and extend healthy lifespan.
- Type
- review
- Published
- 2014-05-21
- Cited by
- 2,386
- References
- 109
- OpenAlex
- https://openalex.org/W2130458932
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:195683447
Keywords
Senescence, Ageing, Biology, Cellular senescence, Cell biology
References
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- Interleukin-6 Maintains Bone Marrow-Derived Mesenchymal Stem Cell Stemness by an ERK1/2-Dependent Mechanism
- BubR1 insufficiency causes early onset of aging-associated phenotypes and infertility in mice
- Opposing roles for p16Ink4a and p19Arf in senescence and ageing caused by BubR1 insufficiency
- p21Waf1 is required for cellular senescence but not for cell cycle arrest induced by the HDAC inhibitor sodium butyrate
- Cdkn1a deletion improves stem cell function and lifespan of mice with dysfunctional telomeres without accelerating cancer formation
- Persistent DNA damage signaling triggers senescence-associated inflammatory cytokine secretion
- Synthetic lethal metabolic targeting of cellular senescence in cancer therapy
- Delayed ageing through damage protection by the Arf/p53 pathway
Cited by
- MicroRNAs and lncRNAs in senescence: A re‐view
- Stem Cell Therapy For Heart Failure: Ensuring Regenerative Proficiency
- Hallmarks of progeroid syndromes: lessons from mice and reprogrammed cells
- Multiple facets of p53 in senescence induction and maintenance
- MicroRNA profiling analysis revealed different cellular senescence mechanisms in human mesenchymal stem cells derived from different origin.
- Ascorbic Acid Attenuates Senescence of Human Osteoarthritic Osteoblasts
- Senescent cells and osteoarthritis: a painful connection
- MicroRNA‐31a‐5p from aging BMSCs links bone formation and resorption in the aged bone marrow microenvironment
- The Role of Na/K-ATPase Signaling in Oxidative Stress Related to Aging: Implications in Obesity and Cardiovascular Disease
- Inhibitory Effect of Lupeol on MMPs Expression using Aged Fibroblast through Repeated UVA Irradiation
- Human skin aging is associated with increased expression of the histone variant H2A.J in the epidermis
- Pathway Profiling Of Replicative And Induced Senescence
- Novel ageing-biomarker discovery using data-intensive technologies.
- Telomere Dysfunction and Cell Senescence in Chronic Lung Diseases: Therapeutic Potential.
- Molecular aspects of renal senescence
- The Role of Stem Cell Genomic Instability in Aging
- Explore Rb/E2F Activation Dynamics to Define the Control Logic of Cell Cycle Entry in Single Cells
- Morphological and ultrastructural examination of senescence in Morchella elata.
- Higher-Order Unfolding of Peri/Centric Satellite Heterochromatin is an Early and Consistent Event in Cell Senescence: A Dissertation
- Proteomic analysis reveals novel common genes modulated in both replicative and stress-induced senescence.
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