Senescence is a developmental mechanism that contributes to embryonic growth and patterning.
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Summary
It is proposed that senescence is a normal programmed mechanism that plays instructive roles in development, and that OIS is an evolutionarily adapted reactivation of a developmental process.
- Type
- article
- Published
- 2013-11-21
- Cited by
- 1,092
- References
- 71
- Access
- Open access
- OpenAlex
- https://openalex.org/W1976635482
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:17699339
Keywords
Biology, Senescence, Embryonic stem cell, Cell biology, Mesenchyme
References
- Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence.
- Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor
- Role of Rel/NF-κB transcription factors during the outgrowth of the vertebrate limb
- Mechanisms of roof plate formation in the vertebrate CNS
- Senescence of activated stellate cells limits liver fibrosis
- Fibroblast growth factors induce additional limb development from the flank of chick embryos.
- Radiation-induced cell cycle arrest compromised by p21 deficiency
- Characterisation and trophic functions of murine embryonic macrophages based upon the use of a Csf1r-EGFP transgene reporter.
- Upregulation of chicken p15INK4b at senescence and in the developing brain
- Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis
- Optical Projection Tomography as a Tool for 3D Microscopy and Gene Expression Studies
- A senescence program controlled by p53 and p16INK4a contributes to the outcome of cancer therapy.
- A series of normal stages in the development of the chick embryo. 1951.
- RNA interference and inhibition of MEK-ERK signaling prevent abnormal skeletal phenotypes in a mouse model of craniosynostosis
- Oncogenic functions of tumour suppressor p21(Waf1/Cip1/Sdi1): association with cell senescence and tumour-promoting activities of stromal fibroblasts.
- Senescent fibroblasts promote epithelial cell growth and tumorigenesis: A link between cancer and aging
- pl5INK4B is a potentia| effector of TGF-β-induced cell cycle arrest
- Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas
- FGF-4 replaces the apical ectodermal ridge and directs outgrowth and patterning of the limb.
- C/EBPbeta at the core of the TGFbeta cytostatic response and its evasion in metastatic breast cancer cells.
Cited by
- MicroRNAs and lncRNAs in senescence: A re‐view
- Pax8 plays a pivotal role in regulation of cardiomyocyte growth and senescence
- Anti‐aging pharmacology in cutaneous wound healing: effects of metformin, resveratrol, and rapamycin by local application
- Micro/nanoelectrochemical probe and chip devices for evaluation of three-dimensional cultured cells.
- Senescent cells and osteoarthritis: a painful connection
- Age and Age-Related Diseases: Role of Inflammation Triggers and Cytokines
- Roles of Apoptosis and Cellular Senescence in Cancer and Aging.
- iPSCs as a major opportunity to understand and cure age-related diseases
- Molecular aspects of renal senescence
- Heparan sulfation is essential for the prevention of cellular senescence
- Higher-Order Unfolding of Peri/Centric Satellite Heterochromatin is an Early and Consistent Event in Cell Senescence: A Dissertation
- Proteomic analysis reveals novel common genes modulated in both replicative and stress-induced senescence.
- Role of the nucleus in apoptosis: signaling and execution
- Autophagy and Cellular Senescence in Lung Diseases
- Forging a signature of in vivo senescence
- Senescence from G2 arrest, revisited
- Evidence for a CDK4-dependent checkpoint in a conditional model of cellular senescence
- Aberrant Autolysosomal Regulation Is Linked to The Induction of Embryonic Senescence: Differential Roles of Beclin 1 and p53 in Vertebrate Spns1 Deficiency
- Tumour suppressors and cellular senescence
- The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4
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