p21Waf1 is required for cellular senescence but not for cell cycle arrest induced by the HDAC inhibitor sodium butyrate

Keywords

Cell biology, Biology, Cell cycle checkpoint, Cell cycle, Sodium butyrate

References

• Quantifying pharmacologic suppression of cellular senescence: prevention of cellular hypertrophy versus preservation of proliferative potentialZoya N. Demidenko, Mikhail V. Blagosklonny — 2009
• Histone deacetylase inhibitors activate p21(WAF1) expression via ATM.Rong Ju, Mark T. Muller — 2003
• Aging-suppressants: Cellular senescence (hyperactivation) and its pharmacologic decelerationMikhail V. Blagosklonny — 2009
• The hallmarks of cancerTony Gutschner, Sven Diederichs — 2012
• Histone deacetylase (HDAC) inhibitor activation of p21WAF1 involves changes in promoter-associated proteins, including HDAC1.C. Gui, Lang Ngo, Weili Xu — 2004
• Rapamycin decelerates cellular senescenceZoya N. Demidenko, С. Г. Зубова, Elena I. Bukreeva — 2009
• Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB.Dos D. Sarbassov, Siraj M. Ali, Shomit Sengupta — 2006
• The power and the promise of oncogene-induced senescence markersManuel Collado, Manuel Serrano — 2006
• Reactivation of Phosphorylated Actin Depolymerizing Factor and Identification of the Regulatory Site (*)Brian Agnew, Laurie S. Minamide, James R. Bamburg — 1995
• Ribosomal protein S6 phosphorylation: from protein synthesis to cell size.Igor Ruvinsky, Oded Meyuhas — 2006
• An expanding role for mTOR in cancer.David A. Guertin, David M. Sabatini — 2005
• Cellular senescence and cancer treatment.Clemens A. Schmitt — 2007
• Activation of ATM-dependent DNA damage signal pathway by a histone deacetylase inhibitor, trichostatin A.Jong‐Soo Lee — 2007
• Cell senescence: Hypertrophic arrest beyond the restriction pointMikhail V. Blagosklonny — 2006
• Activation of the p21WAF1/CIP1 promoter independent of p53 by the histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA) through the Sp1 sitesLili Huang, Yoshihiro Sowa, Toshiyuki Sakai — 2000
• Chromatin structure and DNA double-strand break responses in cancer progression and therapyJessica A. Downs — 2007
• Cross‐talk between Ras and Rho signalling pathways in transformation favours proliferation and increased motilityErik Sahai, Michael F. Olson, C. J. Marshall — 2001
• Aging and Immortality: Quasi-Programmed Senescence and Its Pharmacologic InhibitionMikhail V. Blagosklonny — 2006
• Rho GTPases in cell biologySandrine Etienne‐Manneville, Alan Hall — 2002
• The p65/RelA subunit of NF-kappaB interacts with actin-containing structures.Alexandra F. Are, Vitold E. Galkin, Т. В. Поспелова — 2000

Cited by

• Answering the ultimate question “What is the Proximal Cause of Aging?”Mikhail V. Blagosklonny — 2012
• Rapamycin, proliferation and geroconversion to senescenceYiannakis Sazeides, James E. Smith — 2018
• An integrated approach for monitoring cell senescence.Т. В. Поспелова, Zhanna Chitikova, Valery A. Pospelov — 2013
• Ejercicio y envejecimiento: cambios transcripcionales y epigenéticos en un modelo murino de envejecimiento aceleradoÁlvarez López, María Jesús — 2015
• The Role of Nitric Oxide Dysregulation in Tumor MaintenanceChristopher S. Rabender — 2013
• Histone deacetylase inhibitors cause TP53-dependent induction of p21/Waf1 in tumor cells with TP53 mutationsR. A. Kovalev, Tatiana Shtam, D. V. Karelov — 2015
• NIAM, a novel activator of p53 and potential tumor suppressorSara M. Reed — 2015
• The role of the MEK/ERK pathway in regulation of HDACI-induced senescence of transformed rat embryo fibroblastsElena Kochetkova, Bykova Tv, Zubova Sg — 2014
• Rhus coriaria induces senescence and autophagic cell death in breast cancer cells through a mechanism involving p38 and ERK1/2 activationHussain El Hasasna, Khawlah Athamneh, Halima Al Samri — 2015
• Molecular damage in cancer: an argument for mTOR-driven agingMikhail V. Blagosklonny — 2011
• IκB Kinase β (IKKβ) Inhibits p63 Isoform γ (TAp63γ) Transcriptional Activity*Jun‐Ming Liao, Yu Zhang, Wenjuan Liao — 2013
• Mutations and Deregulation of Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Cascades Which Alter Therapy ResponseJames A. McCubrey, Linda S. Steelman, William H. Chappell — 2012
• Mechanistic or mammalian target of rapamycin (mTOR) may determine robustness in young male mice at the cost of accelerated agingOlga V. Leontieva, Geraldine Paszkiewicz, Mikhail V. Blagosklonny — 2012
• NCI's provocative questions on cancer: some answers to ignite discussionMikhail V. Blagosklonny — 2011
• Novel functions of USP36 : regulation of histone 2B and the P53-MDM2 pathway through deubiquitinationT. Devine — 2015
• Butyrate suppresses murine mast cell proliferation and cytokine production through inhibiting histone deacetylase.Hanying Zhang, ‬Min Du, Qiyuan Yang — 2016
• Latest progress in tyrosine kinase inhibitorsТ. В. Поспелова, Valery A. Pospelov — 2014
• Downregulation of HMGA2 by the pan-deacetylase inhibitor panobinostat is dependent on hsa-let-7b expression in liver cancer cell lines.Pietro Di Fazio, Roberta Montalbano, Daniel Neureiter — 2012
• Rapamycin induces pluripotent genes associated with avoidance of replicative senescenceTatyana V. Pospelova, Tatiana V. Bykova, С. Г. Зубова — 2013
• p21Waf1 is required for complete oncogenic transformation of mouse embryo fibroblasts by E1Aad5 and c-Ha-ras oncogenes.Romanov Vs, Alexander A. Bardin, С. Г. Зубова — 2011

Related papers

• Tumor suppression by p53: making cells senescentYingjuan Qian, Xinbin Chen — 2010
• Paradoxical suppression of cellular senescence by p53Zoya N. Demidenko, Lioubov G. Korotchkina, Andrei V. Gudkov — 2010
• G1 versus G2 cell cycle arrest after adriamycin‐induced damage in mouse Swiss3T3 cellsWai Yi Siu, Cain H. Yam, Randy Y.C. Poon — 1999
• Ligustrazine induces the colorectal cancer cells apoptosis via p53-dependent mitochondrial pathway and cell cycle arrest at the G0/G1 phase.Yaoyao Bian, Lili Yang, Wei Sheng — 2020
• Effect of Marsdenia tenacissima extract on G2/M cell cycle arrest by upregulating 14-3-3σ and downregulating c-myc in vitro and in vivoLi Sun, Qurat Ul Ain, Yingsheng Gao — 2019
• Baculovirus LEF-11 interacts with BmIMPI to induce cell cycle arrest in the G2/M phase for viral replication.Zhanqi Dong, Xinling Zhang, Miao Xiao — 2022