A novel role for high-mobility group a proteins in cellular senescence and heterochromatin formation.
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Summary
This work shows that the High-Mobility Group A (HMGA) proteins accumulate on the chromatin of senescent fibroblasts and are essential structural components of SAHFs, and implies that HMGA proteins also act in tumor suppressor networks.
- Type
- article
- Published
- 2006-08-11
- Cited by
- 639
- References
- 42
- Access
- Open access
- OpenAlex
- https://openalex.org/W1965124005
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:15350606
Keywords
Biology, Heterochromatin, High-mobility group, Senescence, Cellular senescence
References
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- Methylation of histone H3 at Lys-9 is an early mark on the X chromosome during X inactivation.
- Onset of natural killer cell lymphomas in transgenic mice carrying a truncated HMGI-C gene by the chronic stimulation of the IL-2 and IL-15 pathway
- Rb targets histone H3 methylation and HP1 to promoters
- p400 Is Required for E1A to Promote Apoptosis*
- Cloning of short hairpin RNAs for gene knockdown in mammalian cells
- Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors.
- Hoechst 33258, distamycin A, and high mobility group protein I (HMG-I) compete for binding to mouse satellite DNA
- Cytostatic and apoptotic actions of TGF-β in homeostasis and cancer
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- Heterochromatin structure and function
- THE LIMITED IN VITRO LIFETIME OF HUMAN DIPLOID CELL STRAINS.
- High mobility group protein HMGI(Y) enhances tumor cell growth, invasion, and matrix metalloproteinase‐2 expression in prostate cancer cells
- Reversal of human cellular senescence: roles of the p53 and p16 pathways
- Tumour biology: Senescence in premalignant tumours
Cited by
- Transcriptional regulation of cellular senescence
- The tumor suppressor role of CTCF
- Senescence and pre-malignancy: how do tumors progress?
- Induction of cellular senescence by oncogenic RAS.
- Genome-wide RNAi screening to identify regulators of oncogene-induced cellular senescence.
- The senescent hepatocyte gene signature in chronic liver disease.
- Increased SHP-1 expression results in radioresistance, inhibition of cellular senescence, and cell cycle redistribution in nasopharyngeal carcinoma cells
- Oncogene-induced Cellular Senescence
- Detection of senescence-associated heterochromatin foci (SAHF)
- The Function and Regulation of Senescent Stromal-Derived Osteopontin
- Cell senescence as both a dynamic and a static phenotype.
- Apoptosis: Physiology and Pathology
- A genetic screening identifies a component of the SWI/SNF complex, Arid1b as a senescence regulator
- Behaviour of human myoblasts in vitro : role of ageing and inflammatory cytokines
- Investigating Cancer Molecular Genetics using Genome-wide RNA Interference Screens: A Dissertation
- Interactions between mitochondria and inflammatory factors during cellular senescence
- Higher-Order Unfolding of Peri/Centric Satellite Heterochromatin is an Early and Consistent Event in Cell Senescence: A Dissertation
- Prognostic value of HMGA2, CDK4, and JUN amplification in well-differentiated and dedifferentiated liposarcomas
- Myc oncoprotein-cofactor interactions : Function, regulation and targeting
- Induction of cellular senescence as a novel therapeutic strategy for melanoma treatment
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