Neurotrophin signal transduction in the nervous system.
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Summary
A number of novel p75NTR-interacting proteins have been identified that transmit growth, survival, and apoptotic signals.
- Type
- review
- Published
- 2000-06-01
- Cited by
- 2,044
- References
- 139
- OpenAlex
- https://openalex.org/W2128960139
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:16919993
Keywords
Trk receptor, Neurotrophin, Signal transduction, Neuroscience, Receptor
References
- In sympathetic but not sensory neurones, phosphoinositide-3 kinase is important for NGF-dependent survival and the retrograde transport of 125I-βNGF
- Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery.
- p75 Neurotrophin Receptor Expression on Adult Human Oligodendrocytes: Signaling without Cell Death in Response to NGF
- Nerve Growth Factor-Dependent Activation of NF-κB Contributes to Survival of Sympathetic Neurons
- Phosphatidylinositol 3-Kinase and Akt Protein Kinase Are Necessary and Sufficient for the Survival of Nerve Growth Factor-Dependent Sympathetic Neurons
- Nerve Growth Factor Signaling through p75 Induces Apoptosis in Schwann Cells via a Bcl-2-Independent Pathway
- Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene
- Ras Regulates Sympathetic Neuron Survival by Suppressing the p53-Mediated Cell Death Pathway
- Transgenic Mice Expressing the Intracellular Domain of the p75 Neurotrophin Receptor Undergo Neuronal Apoptosis
- The anti-apoptotic protein ITA is essential for NGF-mediated survival of embryonic chick neurons
- The p75 neurotrophin receptor influences NT-3 responsiveness of sympathetic neurons in vivo
- Phosphatidylinositol-3-OH kinase direct target of Ras
- Akt-Dependent Potentiation of L Channels by Insulin-Like Growth Factor-1 Is Required for Neuronal Survival
- A monoclonal antibody modulates the interaction of nerve growth factor with PC12 cells.
- Cyclin Dependent Kinase Inhibitors and Dominant Negative Cyclin Dependent Kinase 4 and 6 Promote Survival of NGF-Deprived Sympathetic Neurons
- Ceramide Signaling Downstream of the p75 Neurotrophin Receptor Mediates the Effects of Nerve Growth Factor on Outgrowth of Cultured Hippocampal Neurons
- Activation of mitogen-activated protein kinase and p70S6 kinase is not correlated with cerebellar granule cell survival.
- Functionally Antagonistic Interactions between the TrkA and p75 Neurotrophin Receptors Regulate Sympathetic Neuron Growth and Target Innervation
- Role of glycogen synthase kinase-3beta in neuronal apoptosis induced by trophic withdrawal.
- Loss of the p53 tumor suppressor gene protects neurons from kainate- induced cell death
Cited by
- Molecular modulation of brain development and function: lessons from “old” and “new”
- Suppression of BDNF‐induced expression of neuropeptide Y (NPY) in cortical cultures by oxygen‐glucose deprivation: A model system to study ischemic mechanisms in the perinatal brain
- ERK regulation in chronic ethanol exposure and withdrawal.
- Pan-neurotrophin receptor p75 contributes to neuronal hyperreactivity and airway inflammation in a murine model of experimental asthma.
- Ca2+-dependent Regulation of TrkB Expression in Neurons*
- An infant with primary tooth loss and palmar hyperkeratosis: a novel mutation in the NTRK1 gene causing congenital insensitivity to pain with anhidrosis.
- Brain-metastatic melanoma: a neurotrophic perspective
- Low‐Affinity Nerve Growth Factor Receptor p75NTR Immunoreactivity in the Myocardium with Sympathetic Hyperinnervation
- Lipid rafts-protein association and the regulation of protein activity.
- Phosphorylated MAPK/ERK1/2 may not always represent its kinase activity in a rat model of focal cerebral ischemia with or without ischemic preconditioning
- Effects of a verbenachalcone derivative on neurite outgrowth, inhibition of caspase induction and gene expression.
- Threshold levels of ERK activation for chemotactic migration differ for NGF and EGF in rat pheochromocytoma PC12 cells
- SLAM-associated Protein as a Potential Negative Regulator in Trk Signaling*
- In vivo induction of glial cell proliferation and axonal outgrowth and myelination by brain-derived neurotrophic factor.
- APPL1 Associates with TrkA and GIPC1 and Is Required for Nerve Growth Factor-Mediated Signal Transduction
- Inhibition of mitogen-activated protein kinase and stimulation of Akt kinase signaling pathways: Two approaches with therapeutic potential in the treatment of neurodegenerative disease.
- Role of nerve growth factor and its receptor in the morphogenesis of neural tube in early chick embryo.
- Postnatal lead exposure alters expression of forebrain p75 and TrkA nerve growth factor receptors.
- Phenotype, compartmental organization and differential vulnerability of nigral dopaminergic neurons.
- p75NTR-dependent modulation of cellular handling of reactive oxygen species
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