Structural and Functional Properties of the TRK Family of Neurotrophin Receptors
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Summary
Characterization of mutant mice lacking each of these tyrosine-kinase receptors by gene targeting in embryonic stem cells is providing relevant information regarding the critical role that these receptors play in the ontogeny of the mammalian nervous system.
- Type
- review
- Published
- 1995-09-01
- Cited by
- 282
- References
- 66
- OpenAlex
- https://openalex.org/W2021002193
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:46584995
Keywords
Trk receptor, Neurotrophin, Receptor, Neuroscience, Medicine
References
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- trkB, a neural receptor protein-tyrosine kinase: evidence for a full-length and two truncated receptors
- Neurotrophin receptor genes are expressed in distinct patterns in developing dorsal root ganglia
- NGF and EGF rapidly activate p21ras in PC12 cells by distinct, convergent pathways involving tyrosine phosphorylation.
- Nerve growth factor stimulates the tyrosine phosphorylation of MAP2 kinase in PC12 cells.
- The cytoplasmic raf oncogene induces a neuronal phenotype in PC12 cells: a potential role for cellular raf kinases in neuronal growth factor signal transduction.
- The rat trkC locus encodes multiple neurogenic receptors that exhibit differential response to neurotrophin-3 in PC12 cells.
- A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction.
- Disruption of the neurotrophin-3 receptor gene trkC eliminates la muscle afferents and results in abnormal movements
- Alternative forms of rat TrkC with different functional capabilities.
- Growth factor signaling by receptor tyrosine kinases.
- Nerve growth factor mediates signal transduction through trk homodimer receptors.
- Dependence on p75 for innervation of some sympathetic targets.
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- Is autism caused by early hyperactivity of brain-derived neurotrophic factor?
- Sympathetic innervation during development is necessary for pancreatic islet architecture and functional maturation
- Rutin upregulates neurotrophic factors resulting in attenuation of ethanol-induced oxidative stress in HT22 hippocampal neuronal cells.
- Apoptosis of Cortical Neurons in Ischemic Insult
- BDNF-TrkB receptor regulation of distributed adult neural plasticity, memory formation, and psychiatric disorders.
- Identification of genes regulated during neuronal apoptosis using oligonucleotide microarrays
- NRAGE Regulates Life and Death of Neural Progenitors
- Peripherally-acting opioids.
- Congenital Insensitivity to Pain with Anhidrosis in an Iranian Patient
- Regulation of the p75 Neurotrophin Receptor in a Rat Myogenic Cell Line (L6)
- Brain-derived neurotrophic factor reduces cortical cell death by ischemia after middle cerebral artery occlusion in the rat
- Role of neurotrophins and neurotrophin receptors in the in vitro invasion and heparanase production of human prostate cancer cells
- Genomic Applications in Pathology
- Pancreatic Disease
- Molecular mechanisms involved in oligodendrocyte development
- Opposing effects of APP/PS1 and TrkB.T1 genotypes on midbrain dopamine neurons and stimulated dopamine release in vivo.
- Expression of nerve growth factor and its receptor, tyrosine kinase receptor A, in rooster testes.
- Nerve growth factor and the physiology of pain: lessons from congenital insensitivity to pain with anhidrosis
- Effects of psychostimulants on neurotrophins implications for psychostimulant-induced neurotoxicity.
- Co-Induction of p75NTR and p75NTR-Associated Death Executor in Neurons After Zinc Exposure in Cortical Culture or Transient Ischemia in the Rat
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