Characterization of neurotrophin and Trk receptor functions in developing sensory ganglia: direct NT-3 activation of TrkB neurons in vivo.
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Summary
It is shown that, during the major period of neurogenesis, NT-3 is required to maintain neurons that express TrkB in addition to those thatexpress TrkC but is not essential for neurons expressing TrkA, and that survival of cells expressing both receptors can be maintained by activation of either one alone.
- Type
- article
- Published
- 1998-08-01
- Cited by
- 205
- References
- 60
- Access
- Open access
- OpenAlex
- https://openalex.org/W2103580807
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:1341262
Keywords
Trk receptor, Tropomyosin receptor kinase B, Tropomyosin receptor kinase C, Tropomyosin receptor kinase A, Neurotrophin
References
- Sensory Neurons: Diversity, Development, and Plasticity
- Non-TrkA-expressing small DRG neurons are lost in TrkA deficient mice
- Developmental changes in NT3 signalling via TrkA and TrkB in embryonic neurons.
- Developmental expression of trkC, the neurotrophin-3 receptor, in the mammalian nervous system
- Synchronous Onset of NGF and TrkA Survival Dependence in Developing Dorsal Root Ganglia
- trkC, a receptor for neurotrophin-3, is widely expressed in the developing nervous system and in non-neuronal tissues.
- Mice lacking nerve growth factor display perinatal loss of sensory and sympathetic neurons yet develop basal forebrain cholinergic neurons.
- TrkA cross-linking mimics neuronal responses to nerve growth factor.
- Timing and site of nerve growth factor synthesis in developing skin in relation to innervation and expression of the receptor
- Disruption of the neurotrophin-3 receptor gene trkC eliminates la muscle afferents and results in abnormal movements
- A local action of neurotrophin-3 prevents the death of proliferating sensory neuron precursor cells.
- Neurotrophin 3 is a mitogen for cultured neural crest cells.
- A BDNF autocrine loop in adult sensory neurons prevents cell death
- Severe sensory and sympathetic deficits in mice lacking neurotrophin-3
- Specific subtypes of cutaneous mechanoreceptors require neurotrophin-3 following peripheral target innervation.
- Novel roles for neurotrophins are suggested by BDNF and NT-3 mRNA expression in developing neurons.
- Severe Sensory Deficits but Normal CNS Development in Newborn Mice Lacking TrkB and TrkC Tyrosine Protein Kinase Receptors
- Proliferation, differentiation, and survival of rat sensory neuron precursors in vitro require specific trophic factors.
- Expression and coexpression of Trk receptors in subpopulations of adult primary sensory neurons projecting to identified peripheral targets.
- Targeted mutation in the neurotrophin-3 gene results in loss of muscle sensory neurons.
Cited by
- Dynamic expression of neurotrophin receptors during sensory neuron genesis and differentiation.
- Phenotypic and Functional Characterization of Peripheral Sensory Neurons derived from Human Embryonic Stem Cells
- In vivo analysis of Trk receptor signalling in the mouse nervous system
- Neurotrophins in the regulation of cellular survival and death.
- Development of an Embryonic Stem Cell-Based Therapy for Replacement of Spiral Ganglion Neurons.
- Reconnecting the CNS and PNS with Stem Cell Transplantation
- Mouse Embryonic Stem Cells Differentiated into Neuron-like Cells or Schwann Cell-like Cells for the Development of Strategies to Ameliorate Deafness.
- Effects of neurotrophin-3 (NT-3) administration on gene expression and dorsal root ganglion neuron loss and repair following axotomy in adult rats.
- Neutrophic factors from three different families have distinct effects on the proliferation and neuronal differentation of embryonic dorsal root ganglion cells
- Inhibition of Retinoic Acid Receptors Results in Defasciculation of the Trigeminal Nerve in Xenopus laevis
- Neurotrophic factors during inner ear development.
- TrkB Isoforms with Distinct Neurotrophin Specificities Are Expressed in Predominantly Nonoverlapping Populations of Avian Dorsal Root Ganglion Neurons
- Molecular pathways of proprioceptive dorsal root ganglion (DRG) sensory neuron specification
- Neuronal function and alpha3 isoform of the Na/K-ATPase.
- Overexpression of neurotrophin‐3 enhances the mechanical response properties of slowly adapting type 1 afferents and myelinated nociceptors
- Axonal transport of BDNF precursor in primary sensory neurons
- Overexpression of Brain-Derived Neurotrophic Factor Enhances Sensory Innervation and Selectively Increases Neuron Number
- Neurotrophins Support the Development of Diverse Sensory Axon Morphologies
- Neurotrophin-3 in the development of the enteric nervous system.
- Developmental Expression of the TTX-Resistant Voltage-Gated Sodium Channels Nav1.8 (SNS) and Nav1.9 (SNS2) in Primary Sensory Neurons
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