Phosphatidylinositol 3-Kinase and Akt Protein Kinase Are Necessary and Sufficient for the Survival of Nerve Growth Factor-Dependent Sympathetic Neurons
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Summary
It is demonstrated that PI 3-kinase and Akt are both necessary and sufficient for the survival of NGF-dependent sympathetic neurons.
- Type
- article
- Published
- 1998-04-15
- Cited by
- 594
- References
- 75
- Access
- Open access
- OpenAlex
- https://openalex.org/W1492349549
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:15615256
Keywords
Wortmannin, Nerve growth factor, Protein kinase B, LY294002, Cell biology
References
- Antiapoptotic signalling by the insulin-like growth factor I receptor, phosphatidylinositol 3-kinase, and Akt
- Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery.
- Insulin stimulates the kinase activity of RAC‐PK, a pleckstrin homology domain containing ser/thr kinase.
- Proliferative inhibition by dominant‐negative Ras rescues naive and neuronally differentiated PC12 cells from apoptotic death.
- Nerve growth factor promotes the activation of phosphatidylinositol 3-kinase and its association with the trk tyrosine kinase.
- A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002).
- Involvement of phosphoinositide 3‐kinase in insulin‐ or IGF‐1‐induced membrane ruffling.
- Inhibition of histamine secretion by wortmannin through the blockade of phosphatidylinositol 3-kinase in RBL-2H3 cells.
- Identification of Trk binding sites for SHC and phosphatidylinositol 3'-kinase and formation of a multimeric signaling complex.
- Phosphatidylinositol-3-OH kinase direct target of Ras
- Phosphatidylinositol 3-kinase is activated by nerve growth factor and epidermal growth factor in PC12 cells.
- PI 3‐kinase: structural and functional analysis of intersubunit interactions.
- Mechanism of activation of protein kinase B by insulin and IGF‐1.
- Direct inhibition of the signaling functions of the mammalian target of rapamycin by the phosphoinositide 3‐kinase inhibitors, wortmannin and LY294002.
- Mice lacking nerve growth factor display perinatal loss of sensory and sympathetic neurons yet develop basal forebrain cholinergic neurons.
- A c-Jun dominant negative mutant protects sympathetic neurons against programmed cell death.
- Analysis of cell cycle-related gene expression in postmitotic neurons: selective induction of Cyclin D1 during programmed cell death.
- DNA-dependent protein kinase catalytic subunit: a relative of phosphatidylinositol 3-kinase and the ataxia telangiectasia gene product.
- Opposing Effects of ERK and JNK-p38 MAP Kinases on Apoptosis
- Role of phosphoinositide 3-OH kinase in cell transformation and control of the actin cytoskeleton by Ras.
Cited by
- Mesangial Cells and Their Adhesive Properties
- Novel strategies and therapeutics for the treatment of prostate carcinoma
- Anterograde and retrograde transport of active extracellular signal-related kinase 1 (ERK1) in the ligated rat sciatic nerve.
- Neuroprotection by scatter factor/hepatocyte growth factor and FGF‐1 in cerebellar granule neurons is phosphatidylinositol 3‐kinase/Akt‐dependent and MAPK/CREB‐independent
- FasL (CD95L/APO-1L) Resistance of Neurons Mediated by Phosphatidylinositol 3-Kinase-Akt/Protein Kinase B-Dependent Expression of Lifeguard/Neuronal Membrane Protein 35
- Inhibition of mitogen-activated protein kinase and stimulation of Akt kinase signaling pathways: Two approaches with therapeutic potential in the treatment of neurodegenerative disease.
- Neuroprotection by NGF and BDNF Against Neurotoxin-Exerted Apoptotic Death in Neural Stem Cells Are Mediated Through Trk Receptors, Activating PI3-Kinase and MAPK Pathways
- Insights into Current Tropomyosin Receptor Kinase (TRK) Inhibitors: Development and Clinical Application
- Influência dos receptores A2a da adenosina no efeito neuroprotector do BDNF na morte neuronal induzida
- Étude des voies de signalisation impliquées dans le contrôle de l’expression de SMN dans des modèles murins d’Amyotrophie Spinale Infantile
- Increased skeletal muscle akt content in a murine model of motor neuron disease
- Cellular Signaling Pathways in Neuronal Apoptosis
- Estudo do efeito neuroprotetor da oxcarbazepina em culturas organotípicas de hipocampo à privação de oxigênio e glicose
- The pros and cons of growth factors and cytokines in peripheral axon regeneration.
- Toll-7 and Toll-6: central nervous system functions as Drosophila neurotrophin receptors
- NRAGE Regulates Life and Death of Neural Progenitors
- Midkine Inhibits Caspase‐Dependent Apoptosis via the Activation of Mitogen‐Activated Protein Kinase and Phosphatidylinositol 3‐Kinase in Cultured Neurons
- Depolarization-dependent pro-survival signaling in spiral ganglion neurons
- Activation of Akt Kinase Inhibits Apoptosis and Changes in Bcl‐2 and Bax Expression Induced by Nitric Oxide in Primary Hippocampal Neurons
- Early decrease of survival signal-related proteins in spinal motor neurons of presymptomatic transgenic mice with a mutant SOD1 gene
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