ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery.
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Summary
It is identified that mTOR phosphorylates a mammalian homologue of Atg13 and the mammalian Atg1 homologues ULK1 and ULK2, which demonstrate that the ULK-Atg13-FIP200 complexes are direct targets of mTOR and important regulators of autophagy in response to mTOR signaling.
- Type
- article
- Published
- 2009-04-01
- Cited by
- 2,029
- References
- 45
- Access
- Open access
- OpenAlex
- https://openalex.org/W2113432343
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:13299035
Keywords
Autophagy-related protein 13, Autophagy, ULK1, Cell biology, PI3K/AKT/mTOR pathway
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Cited by
- Lethal weapons: DAP-kinase, autophagy and cell death: DAP-kinase regulates autophagy.
- Oleanolic acid but not ursolic acid induces cell death in HepG2 cells under starvation-induced autophagy
- Primary resistance to ATP-competitive mTOR inhibitors for the treatment of solid tumors
- Autophagy in Pancreatic Cancer
- p62/SQSTM1/A170: physiology and pathology.
- Studies of the Molecular Mechanism and Signaling Regulation of Autophagy in Saccharomyces Cerevisiae.
- Lack of myotubularin (MTM1) leads to muscle hypotrophy through unbalanced regulation of the autophagy and ubiquitin‐proteasome pathways
- Combined MTOR and autophagy inhibition
- Lipids, lysosomes, and autophagy
- AMPK Regulation of Cell Growth, Apoptosis, Autophagy, and Bioenergetics.
- Lysosomal Biology in Cancer
- Systematic analysis of ATG13 domain requirements for autophagy induction
- Extracellular Vesicles Released from Mycobacterium tuberculosis-Infected Neutrophils Promote Macrophage Autophagy and Decrease Intracellular Mycobacterial Survival
- Sodium fluoride induces splenocyte autophagy via the mammalian targets of rapamycin (mTOR) signaling pathway in growing mice
- Mammalian target of rapamycin: a signaling kinase for every aspect of cellular life.
- Factors affecting CD4 T cell recognition of the EBV-encoded tumour antigen EBNA1
- Effet de la composition en macronutriments de l’aliment sur les mécanismes de contrôle de l’autophagie chez la truite arc-enciel (Oncorhynchus mykiss)
- Nutritional control of cell growth via TOR signaling in budding yeast.
- The Effects of GMS Immunity-Related GTPases on Guanylate-Binding Proteins, Protein Aggregate Formation, and Macroautophagy
- Role of p62/SQSTM1 in Statin Mediated Toxicity in Muscle Cells
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