The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors
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Summary
Recent advances that have been made by research into the role of TLR biology in host defense and disease are described.
- Type
- review
- Published
- 2010-05-01
- Cited by
- 9,119
- References
- 142
- Access
- Open access
- OpenAlex
- https://openalex.org/W2109491705
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:39414949
Keywords
Innate immune system, Pattern recognition receptor, Biology, Acquired immune system, Receptor
References
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- Regulation of Toll/IL-1-receptor-mediated gene expression by the inducible nuclear protein IκBζ
- Cutting Edge: The Immunostimulatory Activity of the Lung Surfactant Protein-A Involves Toll-Like Receptor 41
- Features of systemic lupus erythematosus in Dnase1-deficient mice
- Cutting Edge: Cooperation of IPS-1- and TRIF-Dependent Pathways in Poly IC-Enhanced Antibody Production and Cytotoxic T Cell Responses
- Toll-like receptors: critical proteins linking innate and acquired immunity
- Toll-Like Receptor 9 Signaling Activates NF-κB through IFN Regulatory Factor-8/IFN Consensus Sequence Binding Protein in Dendritic Cells1
- Sequential control of Toll-like receptor–dependent responses by IRAK1 and IRAK2
- Key function for the Ubc13 E2 ubiquitin-conjugating enzyme in immune receptor signaling
- STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity
- Intracellular localization of Toll-like receptor 9 prevents recognition of self DNA but facilitates access to viral DNA
- Ubiquitylation in innate and adaptive immunity
- A Toll-like receptor–independent antiviral response induced by double-stranded B-form DNA
- NLRP3 (NALP3/CIAS1/Cryopyrin) mediates key innate and healing responses to influenza A virus via the regulation of caspase-1
- A Toll-like Receptor That Prevents Infection by Uropathogenic Bacteria
Cited by
- Myeloid DCs in HIV-1 Infection
- Toll-like receptor 4 signaling augments transforming growth factor-β responses: a novel mechanism for maintaining and amplifying fibrosis in scleroderma.
- Novel Changes in NF-κB Activity during Progression and Regression Phases of Hyperplasia
- Inhaled innate immune ligands to prevent pneumonia
- Overexpressing autoimmune regulator regulates the expression of toll-like receptors by interacting with their promoters in RAW264.7 cells.
- The source of human mesenchymal stromal cells influences their TLR profile as well as their functional properties.
- Signaling through Toll‐like receptor 4 and mast cell‐dependent innate immunity responses
- Oncolytic Sindbis virus targets tumors defective in the interferon response and induces significant bystander antitumor immunity in vivo.
- Host-recognition of pathogens and commensals in the mammalian intestine.
- Asymmetric siRNA: New Strategy to Improve Specificity and Reduce Off-Target Gene Expression
- A20 (Tnfaip3) Deficiency in Myeloid Cells Protects against Influenza A Virus Infection
- NMR Studies of Hexaacylated Endotoxin Bound to Wild-type and F126A Mutant MD-2 and MD-2·TLR4 Ectodomain Complexes*
- Intraspecies Variation in the Emergence of Hyperinfectious Bacterial Strains in Nature
- Myd88-Dependent Toll-Like Receptor 7 Signaling Mediates Protection from Severe Ross River Virus-Induced Disease in Mice
- Structure-Activity Relationships in Human Toll-like Receptor 8-Active 2,3-diamino-furo[2,3-c]pyridines
- Association of a functional polymorphism in the promoter region of TLR‐3 with osteoarthritis: A two‐stage case–control study
- Muramyl dipeptide responsive pathways in Crohn’s disease: from NOD2 and beyond
- Traffic control at the “Gut-GALT crossroads”
- Type I interferon in neurological disease-the devil from within.
- TLR Activation Excludes Circulating Naive CD8+ T Cells from Gut-Associated Lymphoid Organs in Mice
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