Cutting Edge: The Immunostimulatory Activity of the Lung Surfactant Protein-A Involves Toll-Like Receptor 41
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Summary
It is demonstrated that SP-A-induced activation of the NF-κB signaling pathway and up-regulation of cytokine synthesis such as TNF-α and IL-10 are critically dependent on the TLR4 functional complex.
- Type
- article
- Published
- 2002-06-15
- Cited by
- 331
- References
- 31
- Access
- Open access
- OpenAlex
- https://openalex.org/W1545754268
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:28853154
Keywords
TLR4, Toll-like receptor, Chinese hamster ovary cell, Surfactant protein A, Collectin
References
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- Extolling the diversity of bacterial endotoxins
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- Comparison of SP-A and LPS effects on the THP-1 monocytic cell line.
- Construction of a lipopolysaccharide reporter cell line and its use in identifying mutants defective in endotoxin, but not TNF-alpha, signal transduction.
- Surfactant protein A differentially regulates IFN-gamma- and LPS-induced nitrite production by rat alveolar macrophages.
- Surfactant Regulation of Host Defense Function in the Lung: A Question of Balance
- Surfactant protein A (SP‐A): the alveolus and beyond
- Effect of surfactant protein A (SP-A) on the production of cytokines by human pulmonary macrophages.
- Surfactant Protein A Inhibits Peptidoglycan-induced Tumor Necrosis Factor-α Secretion in U937 Cells and Alveolar Macrophages by Direct Interaction with Toll-like Receptor 2*
- Structure and function of Toll-like receptor proteins.
- Human TLR9 confers responsiveness to bacterial DNA via species-specific CpG motif recognition
- Calcium dependent association of surfactant protein A with pulmonary surfactant: application to simple surfactant protein A purification.
- Surfactant Proteins A and D Bind CD14 by Different Mechanisms*
- Inactivation of Endotoxin by Polymyxin B
- The role of surfactant-associated protein A in pulmonary host defense
- Fibrinogen Stimulates Macrophage Chemokine Secretion Through Toll-Like Receptor 41
- Expression of PKA inhibitor ( PKI) gene abolishes cAMPmediated protection to endothelial barrier dysfunction.
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- Injury, sepsis, and the regulation of Toll‐like receptor responses
- Toll-like receptors (TLRs) in transplantation
- Toll-Like Receptor 4 Activation in Cancer Progression and Therapy
- Trial Watch
- Gene Expression Quantification of Toll like Receptors 2, 4 and Co-molecules in Human Glioblastoma Cell Line (U87-MG): Toward a New In vitro Model of Inflammation
- Heat shock proteins in immunity.
- Pattern recognition by Toll-like receptors.
- No Longer an Innocent Bystander: Epithelial Toll-Like Receptor Signaling in the Development of Mucosal Inflammation
- Immunologie de la polypose nasosinusienne
- Pathophysiology of chronic rhinosinusitis, pharmaceutical therapy options
- Expression et fonctionnalité des Toll-Like récepteurs par les cellules de leucémie lymphoïde chronique B
- Mucosal immunity in mycobacterial infections.
- A study of the modulation of Toll-like receptor signalling in macrophages by Annexin-1
- The Role of Caveolin-1 and Surfactant Protein A as Regulators of Airway Hyperreactivity and Inflammation Following Innate Immune Challenges
- Udział receptorów TLR rozpoznających wzorce molekularne organizmów patogennych w modulowaniu aktywności regulatorowych limfocytów T CD4+CD25+FoxP3+
- Lung surfactant proteins A and D as pattern recognition proteins.
- Toll-Like Receptors at the Maternal–Fetal Interface in Normal Pregnancy and Pregnancy Disorders
- SP-D and regulation of the pulmonary innate immune system in allergic airway changes
- Genes of innate immunity and the biological response to inhaled ozone
- Danger‐associated molecular patterns (DAMPs) in acute lung injury
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- Direct binding of toll-like receptor 2 to zymosan, and zymosan-induced NF-κB activation and TNF-α secretion are downregulated by lung collectin surfactant protein A