Cutting Edge: The Immunostimulatory Activity of the Lung Surfactant Protein-A Involves Toll-Like Receptor 41

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Summary

It is demonstrated that SP-A-induced activation of the NF-κB signaling pathway and up-regulation of cytokine synthesis such as TNF-α and IL-10 are critically dependent on the TLR4 functional complex.

Type
article
Published
2002-06-15
Cited by
331
References
31
Access
Open access

Keywords

TLR4, Toll-like receptor, Chinese hamster ovary cell, Surfactant protein A, Collectin

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