A phase 2 study of bortezomib in relapsed, refractory myeloma.
Explore this paper's citation graph
Summary
Bortezomib, a member of a new class of anticancer drugs, is active in patients with relapsed multiple myeloma that is refractory to conventional chemotherapy.
- Type
- article
- Published
- 2003-06-26
- Cited by
- 2,704
- References
- 45
- Access
- Open access
- OpenAlex
- https://openalex.org/W2108235071
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:31966482
Keywords
Medicine, Bortezomib, Multiple myeloma, Neutropenia, Internal medicine
References
- Multiple myeloma cell adhesion-induced interleukin-6 expression in bone marrow stromal cells involves activation of NF-kappa B.
- Survival analysis using the SAS system : a practical guide
- Lack of multicellular drug resistance observed in human ovarian and prostate carcinoma treated with the proteasome inhibitor PS-341.
- NF-kappa B as a therapeutic target in multiple myeloma.
- Vascular endothelial growth factor-induced migration of multiple myeloma cells is associated with beta 1 integrin- and phosphatidylinositol 3-kinase-dependent PKC alpha activation.
- In vivo ubiquitination and proteasome-mediated degradation of p53(1).
- Molecular mechanisms of novel therapeutic approaches for multiple myeloma
- CRITERIA FOR EVALUATING DISEASE RESPONSE AND PROGRESSION IN PATIENTS WITH MULTIPLE MYELOMA TREATED BY HIGH‐DOSE THERAPY AND HAEMOPOIETIC STEM CELL TRANSPLANTATION
- Molecular sequelae of proteasome inhibition in human multiple myeloma cells
- Cut8, essential for anaphase, controls localization of 26S proteasome, facilitating destruction of cyclin and Cut2.
- Activation of NF-κB and upregulation of intracellular anti-apoptotic proteins via the IGF-1/Akt signaling in human multiple myeloma cells: therapeutic implications
- Enhancement of radiosensitivity by proteasome inhibition: implications for a role of NF-kappaB.
- Phase III Study Comparing Vincristine, Doxorubicin (Adriamycin), and Dexamethasone (VAD) Chemotherapy with VAD Plus Recombinant Interferon Alfa‐2 in Refractory or Relapsed Multiple Myeloma: An Eastern Cooperative Oncology Group Study
- Proteasome inhibitors: from research tools to drug candidates.
- The role of tumor necrosis factor alpha in the pathophysiology of human multiple myeloma: therapeutic applications.
- 26S proteasome inhibition induces apoptosis and limits growth of human pancreatic cancer
- Chemosensitization of pancreatic cancer by inhibition of the 26S proteasome.
- Role of the ubiquitin-proteasome pathway in regulating abundance of the cyclin-dependent kinase inhibitor p27.
- Treatment Approaches for Relapsing and Refractory Multiple Myeloma
- Novel proteasome inhibitor PS-341 inhibits activation of nuclear factor-kappa B, cell survival, tumor growth, and angiogenesis in squamous cell carcinoma.
Cited by
- Investigation of the intrinsic mechanism of drug resistance in multiple myeloma
- Cost effectiveness of bortezomib in the treatment of advanced multiple myeloma.
- Proteasome Inhibitor Bortezomib Enhances the Activity of Multiple Mutant Forms of Lysosomal α-Glucosidase in Pompe Disease.
- Interruption of the NF-kappaB pathway by Bay 11-7082 promotes UCN-01-mediated mitochondrial dysfunction and apoptosis in human multiple myeloma cells.
- Pancreatic Cancer Experimental and Clinical Studies
- Transforming Growth Factor β Receptor I Kinase Inhibitor Down-Regulates Cytokine Secretion and Multiple Myeloma Cell Growth in the Bone Marrow Microenvironment
- Morphoproteomics: exposing protein circuitries in tumors to identify potential therapeutic targets in cancer patients
- Sulindac Enhances the Proteasome Inhibitor Bortezomib-Mediated Oxidative Stress and Anticancer Activity
- The ubiquitin-proteasome pathway and its role in cancer.
- Toxic neuropathy
- Advances in the management of myeloma bone disease
- Risk stratification of patients with newly diagnosed multiple myeloma: optimizing treatment based on pretreatment characteristics.
- Overview of drug therapy for multiple myeloma
- Proteasome inhibitor bortezomib impairs both myelofibrosis and osteosclerosis induced by high thrombopoietin levels in mice.
- Bortezomib significantly impairs the immunostimulatory capacity of human myeloid blood dendritic cells
- Review of peripheral neuropathy in plasma cell disorders
- Bortezomib, doxorubicin and dexamethasone in advanced multiple myeloma.
- Bortezomib plus melphalan and prednisone for initial treatment of multiple myeloma.
- Bortezomib overcomes cell adhesion-mediated drug resistance through downregulation of VLA-4 expression in multiple myeloma
- Pegylated liposomal doxorubicin plus bortezomib in relapsed or refractory multiple myeloma: efficacy and safety in patients with renal function impairment.
Related papers
- Bortezomib in combination with thalidomide-dexamethasone for previously untreated multiple myeloma
- Bortezomib in combination with low-dose oral melphalan, dexamethasone and thalidomide for relapsed elderly patients with multiple myeloma
- Rapid control of previously untreated multiple myeloma with bortezomib–lenalidomide–dexamethasone (BLD)
- Hematology: Setting the standard for newly diagnosed multiple myeloma
- Impact of prior therapies on the relative efficacy of bortezomib compared with dexamethasone in patients with relapsed/refractory multiple myeloma
- Bortezomib for the treatment of multiple myeloma
- Efficacy of Low-dosage Bortezomib Combination with Dexamethasone,THP and Thalidomide for Multiple Myeloma
- Activity of panobinostat in combination with bortezomib and dexamethasone in advanced, proteasome inhibitor refractory multiple myeloma