Sulindac Enhances the Proteasome Inhibitor Bortezomib-Mediated Oxidative Stress and Anticancer Activity
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Summary
Sulindac synergistically augments the anticancer effects of bortezomib primarily through cooperative ROS generation and oxidative DNA damage, thereby representing a novel combination therapy against colon cancer.
- Type
- article
- Published
- 2005-07-15
- Cited by
- 66
- References
- 47
- Access
- Open access
- OpenAlex
- https://openalex.org/W16033843
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:14707262
Keywords
Computer science
References
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- Apoptosis primarily accounts for the growth-inhibitory properties of sulindac metabolites and involves a mechanism that is independent of cyclooxygenase inhibition, cell cycle arrest, and p53 induction.
- THE TREATMENT OF MULTIPLE MYELOMA
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- Induction of multidrug resistance proteins MRP1 and MRP3 and gamma-glutamylcysteine synthetase gene expression by nonsteroidal anti-inflammatory drugs in human colon cancer cells.
- Initiation of DNA Fragmentation during Apoptosis Induces Phosphorylation of H2AX Histone at Serine 139*
- Mechanisms underlying nonsteroidal antiinflammatory drug-mediated apoptosis.
- Primary chemoprevention of familial adenomatous polyposis with sulindac: more questions than answers.
- Molecular ordering of ROS production, mitochondrial changes, and caspase activation during sodium salicylate-induced apoptosis.
- Intrinsic oxidative stress in cancer cells: a biochemical basis for therapeutic selectivity
- Vaccine entrapment in liposomes.
- Combination of tumor necrosis factor‐α with sulindac augments its apoptotic potential and suppresses tumor growth of human carcinoma cells in nude mice
- Expression of the antioxidant stress protein heme oxygenase-1 (HO-1) in human leukocytes.
- Reactive Oxygen Species Generation and Mitochondrial Dysfunction in the Apoptotic Response to Bortezomib, a Novel Proteasome Inhibitor, in Human H460 Non-small Cell Lung Cancer Cells*
- Effects of nonsteroidal anti-inflammatory drugs on proliferation and on induction of apoptosis in colon cancer cells by a prostaglandin-independent pathway.
Cited by
- Berberine, a natural product, combined with cisplatin enhanced apoptosis through a mitochondria/caspase-mediated pathway in HeLa cells.
- Oxidative Stress by Targeted Agents Promotes Cytotoxicity in Hematologic Malignancies
- Nonsteroidal anti-inflammatory drugs and oxidative stress in cancer cells.
- New methods to screen for cancer drugs and to evaluate their mechanism of action.
- Induction of caspase-dependent death by proteasome targeted therapy in glioblastoma
- Mitochondrial thioredoxin reductase regulates major cytotoxicity pathways of proteasome inhibitors in multiple myeloma cells
- Sulindac induces apoptotic cell death in susceptible human breast cancer cells through, at least in part, inhibition of IKKβ
- Synergistic induction of apoptosis by sulindac and arsenic trioxide in human lung cancer A549 cells via reactive oxygen species-dependent down-regulation of survivin.
- Bortezomib in combination with celecoxib in patients with advanced solid tumors: a phase I trial
- Preadministration of High-Dose Salicylates, Suppressors of NF-κB Activation, May Increase the Chemosensitivity of Many Cancers: An Example of Proapoptotic Signal Modulation Therapy
- Reactive oxygen species: Current knowledge and applications in cancer research and therapeutic
- Synergistic Effect of Sulindac and Simvastatin on Apoptosis in Lung Cancer A549 Cells through AKT-Dependent Downregulation of Survivin
- Characterization of a Microsphere Formulation Containing Glucose Oxidase and its In Vivo Efficacy in a Murine Solid Tumor Model
- Proteasome inhibitor induces apoptosis through induction of endoplasmic reticulum stress
- 5-(4-Chlorophenyl)-1-(4-methoxyphenyl)-3-trifluoromethylpyrazole acts in a reactive oxygen species-dependent manner to suppress human lung cancer growth
- Alpha-tocopheryl succinate sensitizes human colon cancer cells to exisulind-induced apoptosis
- Response of Dictyostelium discoideum to UV‐C and involvement of poly (ADP‐ribose) polymerase
- Caspase-2 activation in neural stem cells undergoing oxidative stress-induced apoptosis
- Additive inhibition of colorectal cancer cell lines by aspirin and bortezomib
- p38MAPK inhibitor SB203580 sensitizes human SNU-C4 colon cancer cells to exisulind-induced apoptosis.
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