The role of tumor necrosis factor alpha in the pathophysiology of human multiple myeloma: therapeutic applications.
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Summary
The proteasome inhibitor PS-341 abrogated TNFalpha-induced NF-kappaB activation, induction of ICAM-1 or VCAM1, and increased adhesion of MM cells to BMSCs, with related IL-6 secretion.
- Type
- article
- Published
- 2001-07-27
- Cited by
- 366
- References
- 0
- OpenAlex
- https://openalex.org/W2070739194
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:11208774
Keywords
Stromal cell, Tumor necrosis factor alpha, Biology, Cancer research, Cell adhesion molecule
References
No references recorded for this paper.
Cited by
- Effect of artesunate on inhibiting proliferation and inducing apoptosis of SP2/0 myeloma cells through affecting NFκB p65
- The Clinically Approved Proteasome Inhibitor PS-341 Efficiently Blocks Influenza A Virus and Vesicular Stomatitis Virus Propagation by Establishing an Antiviral State
- Multiple myeloma
- Pathogenesis beyond the cancer clone(s) in multiple myeloma.
- Single cell functional analysis of multiple myeloma cell populations correlates with diffusion profiles in static microfluidic coculture systems.
- Targeting α4 Integrin Containing Complexes in Multiple Myeloma Using Peptidomimetics
- The role of the bone marrow microenvironment in multiple myeloma.
- Copper-zinc superoxide dismutase and glucose metabolism as redox targets for bortezomib resistance in multiple myeloma
- Bortezomib (PS-341): a novel, first-in-class proteasome inhibitor for the treatment of multiple myeloma and other cancers.
- ROLE DES MEMBRES DE LA FAMILLE BAFF/APRIL DANS LE MYELOME MULTIPLE : IMPLICATIONS PHYSIOPATHOLOGIQUES ET INTERET THERAPEUTIQUE
- The role of the tumor microenvironment in hematological malignancies and implication for therapy.
- Multiple myeloma: the bone marrow microenvironment and its relation to treatment
- Dynamics of tumor progression and therapy response in Il-6 and Myc driven plasma cell malignancy
- IL-3-Mediated Osteoblast Inhibition in Multiple Myeloma
- The role of the bone marrow microenvironment in the establishment and progression of multiple myeloma
- Molecular Targeting and Signal Transduction
- Combination of Dasatinib and Dexamethasone targets the myeloma plasma cell through its interaction with the bone marrow microenvironment
- The microenvironment and molecular biology of the multiple myeloma tumor.
- Pharmacogenetic studies in multiple myeloma
- Genetic variations in multiple myeloma I: effect on risk of multiple myeloma
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