Transforming Growth Factor β Receptor I Kinase Inhibitor Down-Regulates Cytokine Secretion and Multiple Myeloma Cell Growth in the Bone Marrow Microenvironment

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Summary

It is shown that the TGF-β receptor I kinase inhibitor SD-208 significantly decreases secretion of both IL-6 and vascular endothelial growth factor (VEGF) from B MSCs, as well as tumor cell growth triggered by MM cell adhesion to BMSCs.

Type
article
Published
2004-11-15
Cited by
105
References
32
Access
Open access

Keywords

Humanities, Philosophy

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