Vascular endothelial growth factor-induced migration of multiple myeloma cells is associated with beta 1 integrin- and phosphatidylinositol 3-kinase-dependent PKC alpha activation.
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Summary
It is shown that protein kinase C (PKC) alpha is translocated to the plasma membrane and activated by adhesion of MM cells to fibronectin and VEGF, and it is demonstrated that PKC alpha is constitutively associated with beta(1) integrin.
- Type
- article
- Published
- 2002-03-01
- Cited by
- 183
- References
- 3
- Access
- Open access
- OpenAlex
- https://openalex.org/W1761234319
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:83417705
Keywords
Cell biology, Integrin, Fibronectin, Integrin-linked kinase, Protein kinase C
References
Cited by
- Integrin β7-mediated regulation of multiple myeloma cell adhesion, migration, and invasion.
- ROLE DES MEMBRES DE LA FAMILLE BAFF/APRIL DANS LE MYELOME MULTIPLE : IMPLICATIONS PHYSIOPATHOLOGIQUES ET INTERET THERAPEUTIQUE
- macroglobulinemia SDF-1/CXCR4 and VLA-4 interaction regulates homing in Waldenstrom
- The selective adhesion molecule inhibitor Natalizumab decreases multiple myeloma cell growth in the bone marrow microenvironment: therapeutic implications
- Charakterisierung von Interleukin-16 als therapeutische Zielstruktur im Multiplen Myelom
- Analysis of Spontaneous vs. Vaccine-induced Antibody Responses against Antigens MAGE-A3 and MAGE-C2 in Cancer Patients
- Preclinical Evaluation of a Novel SIRT1 Modulator SRT1720 in Multiple Myeloma Cells
- Association of clinicopathologic parameters with the expression of inducible nitric oxide synthase and vascular endothelial growth factor in mucoepidermoid carcinoma.
- YB-1 is a Transcription/Translation Factor that Orchestrates the Oncogenome by Hardwiring Signal Transduction to Gene Expression
- A functional characterisation of the dimerisation motif in fibronectin, in vivo and in vitro
- Melanoma Vasculogenic Mimicry Capillary‐Like Structure Formation Depends on Integrin and Calcium Signaling
- Tetracycline Regulated Systems in Functional Oncogenomics
- A paracrine loop in the vascular endothelial growth factor pathway triggers tumor angiogenesis and growth in multiple myeloma.
- Signaling pathways involved in B cell differentiation and disease : the role of Ral, Btk and Met
- Extravasation and homing mechanisms in multiple myeloma
- A novel orally active proteasome inhibitor ONX 0912 triggers in vitro and in vivo cytotoxicity in multiple myeloma.
- MET dysregulation is a hallmark of aggressive disease in multiple myeloma patients
- Novel biologically based therapeutic strategies in myeloma.
- The small-molecule VEGF receptor inhibitor pazopanib (GW786034B) targets both tumor and endothelial cells in multiple myeloma
- PKCα promotes the mesenchymal to amoeboid transition and increases cancer cell invasiveness
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