Vascular endothelial growth factor-induced migration of multiple myeloma cells is associated with beta 1 integrin- and phosphatidylinositol 3-kinase-dependent PKC alpha activation.

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Summary

It is shown that protein kinase C (PKC) alpha is translocated to the plasma membrane and activated by adhesion of MM cells to fibronectin and VEGF, and it is demonstrated that PKC alpha is constitutively associated with beta(1) integrin.

Type
article
Published
2002-03-01
Cited by
183
References
3
Access
Open access

Keywords

Cell biology, Integrin, Fibronectin, Integrin-linked kinase, Protein kinase C

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