Wnt/β-Catenin/Tcf Signaling Induces the Transcription of Axin2, a Negative Regulator of the Signaling Pathway
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Summary
The results strongly suggest that Axin2 is a direct target of the Wnt pathway, mediated through Tcf/LEF factors, and participates in a negative feedback loop which could serve to limit the duration or intensity of a Wnt-initiated signal.
- Type
- article
- Published
- 2002-02-01
- Cited by
- 1,759
- References
- 59
- Access
- Open access
- OpenAlex
- https://openalex.org/W2102512718
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:23789187
Keywords
AXIN2, Biology, Wnt signaling pathway, Regulator, Signal transduction
References
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- Phosphorylation of Axin, a Wnt Signal Negative Regulator, by Glycogen Synthase Kinase-3β Regulates Its Stability*
- Synergy between tumor suppressor APC and the beta-catenin-Tcf4 target Tcf1.
- Domains of axin and disheveled required for interaction and function in wnt signaling.
- Linking colorectal cancer to Wnt signaling.
Cited by
- Negative Feedback Loop of Wnt Signaling through Upregulation of Conductin/Axin2 in Colorectal and Liver Tumors
- Adenomatous polyposis coli‐deficient zebrafish are susceptible to digestive tract neoplasia
- Drosophila split ends homologue SHARP functions as a positive regulator of Wnt/beta-catenin/T-cell factor signaling in neoplastic transformation.
- Dkk1 and Wnt3 interact to control head morphogenesis in the mouse
- Regulation of Epithelial Branching Morphogenesis and Cancer Cell Growth of the Prostate by Wnt Signaling
- Wnt-mediated self-renewal of neural stem/progenitor cells
- Both the RGS Domain and the Six C-Terminal Amino Acids of Mouse Axin Are Required for Normal Embryogenesis
- Conservation and Diversification of an Ancestral Chordate Gene Regulatory Network for Dorsoventral Patterning
- Tissue-specific roles of Axin2 in the inhibition and activation of Wnt signaling in the mouse embryo
- Expression and Functional Analysis of Dkk1 during Early Gonadal Development
- Association of AXIN2 with Non-syndromic Oral Clefts in Multiple Populations
- Gbx2 Directly Restricts Otx2 Expression to Forebrain and Midbrain, Competing with Class III POU Factors
- Activation of canonical WNT/β-catenin signaling enhances in vitro motility of glioblastoma cells by activation of ZEB1 and other activators of epithelial-to-mesenchymal transition.
- Canonical Wnt signaling regulates smooth muscle precursor development in the mouse ureter
- Analysis of human samples reveals impaired SHH-dependent cerebellar development in Joubert syndrome/Meckel syndrome
- The Wnt signalling pathway is upregulated in an in vitro model of acquired tamoxifen resistant breast cancer
- IGF antagonizes the Wnt/β-Catenin pathway and promotes differentiation of extra-embryonic endoderm.
- β-Catenin Signaling Drives Differentiation and Proinflammatory Function of IRF8-Dependent Dendritic Cells
- Wnt signaling induces transcription, spatial proximity, and translocation of fusion gene partners in human hematopoietic cells.
- The molecular and cellular signatures of the mouse eminentia thalami support its role as a signalling centre in the developing forebrain
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