Activation of canonical WNT/β-catenin signaling enhances in vitro motility of glioblastoma cells by activation of ZEB1 and other activators of epithelial-to-mesenchymal transition.
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Summary
It is shown that activation of the canonical WNT/β-catenin pathway increases the expression of stem cell genes and promotes the migratory and invasive capacity of glioblastoma.
- Type
- article
- Published
- 2012-12-01
- Cited by
- 229
- References
- 66
- OpenAlex
- https://openalex.org/W22652173
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:39825460
Keywords
Computer science
References
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Cited by
- The Wnt signalling pathway is upregulated in an in vitro model of acquired tamoxifen resistant breast cancer
- Telomerase reverse transcriptase potentially promotes the progression of oral squamous cell carcinoma through induction of epithelial-mesenchymal transition.
- Thermodynamics in Gliomas: Interactions between the Canonical WNT/Beta-Catenin Pathway and PPAR Gamma
- Antrodia cinnamomea mycelial fermentation broth inhibits the epithelial-mesenchymal transition of human esophageal adenocarcinoma cancer cells.
- Wnt signaling transcription factors TCF-1 and LEF-1 are upregulated in malignant astrocytic brain tumors.
- KITENIN promotes glioma invasiveness and progression, associated with the induction of EMT and stemness markers
- ZEB1 PROMOTES INVASION IN HUMAN FETAL NEURAL STEM CELLS AND HYPOXIC GLIOMA NEUROSPHERES
- Cisplatin-selected resistance is associated with increased motility and stem-like properties via activation of STAT3/Snail axis in atypical teratoid/rhabdoid tumor cells
- Radioactive 125I seeds inhibit cell growth and epithelial-mesenchymal transition in human glioblastoma multiforme via a ROS-mediated signaling pathway
- Inhibition of histamine receptor 3 suppresses glioblastoma tumor growth, invasion, and epithelial-to-mesenchymal transition
- Mechanical induction of the tumorigenic β-catenin pathway by tumour growth pressure
- ZEB1: At the crossroads of epithelial-mesenchymal transition, metastasis and therapy resistance
- Treatment of glioblastoma multiforme using combination of siRNA targeting EGFR and β-catenin
- MicroRNA-542-3p Suppresses Tumor Cell Invasion via Targeting AKT Pathway in Human Astrocytoma*
- Stem Cell Niches in Glioblastoma: A Neuropathological View
- Osthole inhibits insulin-like growth factor-1-induced epithelial to mesenchymal transition via the inhibition of PI3K/Akt signaling pathway in human brain cancer cells.
- Correlation between EGFR Amplification and the Expression of MicroRNA-200c in Primary Glioblastoma Multiforme
- CD133/CD15 defines distinct cell subpopulations with differential in vitro clonogenic activity and stem cell-related gene expression profile in in vitro propagated glioblastoma multiforme-derived cell line with a PNET-like component.
- PRDM1 is directly targeted by miR-30a-5p and modulates the Wnt/β-catenin pathway in a Dkk1-dependent manner during glioma growth.
- Taking advantage of neural development to treat glioblastoma
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