A GSK3beta phosphorylation site in axin modulates interaction with beta-catenin and Tcf-mediated gene expression.
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Summary
It is reported that Axin is phosphorylated on Ser and Thr residues in several regions in vivo, while only one region (amino acids 600-672) is efficiently phosphorylation by GSK3beta in vitro.
- Type
- article
- Published
- 1999-12-01
- Cited by
- 49
- References
- 0
- Access
- Open access
- OpenAlex
- https://openalex.org/W2003637983
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:30988435
Keywords
Dishevelled, Phosphorylation, Wnt signaling pathway, Dephosphorylation, Cell biology
References
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Cited by
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- Kidney Induction: Control by Notch, Wnt and GDNF/Ret signalling
- The effects of Sulf1 on canonical and non-canonical Wnt signalling in Xenopus
- Characterisation of a novel culture condition for the establishment and maintenance of mouse embryonic stem cells and implications for the mechanisms of self-renewal
- GSK-3 as potential target for therapeutic intervention in cancer
- GSK-3: Functional Insights from Cell Biology and Animal Models
- GSK-3: tricks of the trade for a multi-tasking kinase
- New insights into the regulation of Axin function in canonical Wnt signaling pathway
- Direct Inhibition of GSK3β by the Phosphorylated Cytoplasmic Domain of LRP6 in Wnt/β-Catenin Signaling
- SUMOylation target sites at the C terminus protect Axin from ubiquitination and confer protein stability
- Role of Glycogen Synthase Kinase-3 in Cell Fate and Epithelial-Mesenchymal Transitions
- Wnt/beta-Catenin Signaling and Small Molecule Inhibitors
- Distinct molecular forms of β-catenin are targeted to adhesive or transcriptional complexes
- Wnt stabilization of β-catenin reveals principles for morphogen receptor-scaffold assemblies
- Regulation of Wnt/β-Catenin Signaling by Protein Kinases
- Protein phosphatase 1 regulates assembly and function of the β‐catenin degradation complex
- GSK3β/Axin-1/β-Catenin Complex Is Involved in Semaphorin3A Signaling
- Methylation by protein arginine methyltransferase 1 increases stability of Axin, a negative regulator of Wnt signaling
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