Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells
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Summary
PC1 and PC2 contribute to fluid-flow sensation by the primary cilium in renal epithelium and that they both function in the same mechanotransduction pathway, suggesting loss or dysfunction of PC1 or PC2 may lead to polycystic kidney disease.
- Type
- article
- Published
- 2003-02-01
- Cited by
- 2,089
- References
- 50
- OpenAlex
- https://openalex.org/W2095869636
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:23149223
Keywords
Cilium, Mechanosensation, PKD1, Biology, Polycystic kidney disease
References
- Cystin, a novel cilia-associated protein, is disrupted in the cpk mouse model of polycystic kidney disease.
- Polycystin expression during embryonic development of human kidney in adult tissues and ADPKD tissue
- Co-assembly of polycystin-1 and -2 produces unique cation-permeable currents
- Late onset of renal and hepatic cysts in Pkd1-targeted heterozygotes
- Developmental changes in ryanodine- and IP(3)-sensitive Ca(2+) pools in ovine basilar artery.
- Flow-mediated endothelial mechanotransduction.
- The Oak Ridge Polycystic Kidney (orpk) disease gene is required for left-right axis determination.
- Polycystin, the polycystic kidney disease 1 protein, is expressed by epithelial cells in fetal, adult, and polycystic kidney.
- Polycystin-2 localizes to kidney cilia and the ciliary level is elevated in orpk mice with polycystic kidney disease.
- Candidate gene associated with a mutation causing recessive polycystic kidney disease in mice.
- Coordinate expression of the autosomal dominant polycystic kidney disease proteins, polycystin-2 and polycystin-1, in normal and cystic tissue.
- Protease-activated receptors: sentries for inflammation?
- Molecular cloning, cDNA sequence analysis, and chromosomal localization of mouse Pkd2.
- Polycystin-2, the protein mutated in autosomal dominant polycystic kidney disease (ADPKD), is a Ca2+-permeable nonselective cation channel.
- The propulsion of mucus by cilia.
- The polycystic kidney disease-1 protein, polycystin-1, binds and activates heterotrimeric G-proteins in vitro.
- Four color immunofluorescence detection using two 488-nm lasers on a Becton Dickinson FACS Vantage flow cytometer.
- Bending the MDCK Cell Primary Cilium Increases Intracellular Calcium
- Polycystin channels and kidney disease.
- Mutant sensory cilia in the nematode Caenorhabditis elegans.
Cited by
- Structure-function relationship of the TRP channel superfamily.
- Polycystin-1 Distribution Is Modulated by Polycystin-2 Expression in Mammalian Cells*
- PKD2 cation channel is required for directional sperm movement and male fertility.
- Modeling ciliopathies: Primary cilia in development and disease.
- Intraflagellar transport and cilia-dependent renal disease: the ciliary hypothesis of polycystic kidney disease.
- Stress models for the study of intermediate filament function.
- The remarkable mechanical strength of polycystin-1 supports a direct role in mechanotransduction.
- Emerging roles for renal primary cilia in epithelial repair.
- Mechanisms of mechanotransduction.
- The emerging complexity of the vertebrate cilium: new functional roles for an ancient organelle.
- TRPP2 channel regulation.
- Prime time for polycystic kidney disease: does one shot of roscovitine bring the cure?
- Polycystic Kidneys Caused by Sustained Expression of Cux1 Isoform p75*
- Strategies to inhibit cyst formation in ADPKD.
- Syndromes, disorders and maternal risk factors associated with neural tube defects (III).
- Thermosensory and mechanosensory perception in human genetic disease.
- Polycystins play a key role in the modulation of cholangiocyte proliferation.
- Single-molecule force spectroscopy of polycystic kidney disease proteins.
- Mechanical stimulation of polycystin-1 induces human osteoblastic gene expression via potentiation of the calcineurin/NFAT signalling axis
- G-protein signaling modulator 1 deficiency accelerates cystic disease in an orthologous mouse model of autosomal dominant polycystic kidney disease
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