The Oak Ridge Polycystic Kidney (orpk) disease gene is required for left-right axis determination.
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Summary
It is proposed that the failure of ventral node cells to fully mature alters their ability to undergo differentiation as they migrate out of the node to contribute to the developing midline structures.
- Type
- article
- Published
- 2000-06-01
- Cited by
- 461
- References
- 31
- OpenAlex
- https://openalex.org/W1962669878
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:8166577
Keywords
Biology, Polycystic kidney disease, Allele, Genetics, Mutation
References
- Insertional mutagenesis and molecular analysis of a new gene associated with polycystic kidney disease.
- Cdc16p, Cdc23p and Cdc27p form a complex essential for mitosis.
- Pitx2 determines left–right asymmetry of internal organs in vertebrates
- Cloning of inv, a gene that controls left/right asymmetry and kidney development
- Mutation of an axonemal dynein affects left–right asymmetry in inversus viscerum mice
- Differential rescue of the renal and hepatic disease in an autosomal recessive polycystic kidney disease mouse mutant. A new model to study the liver lesion.
- Impact of node ablation on the morphogenesis of the body axis and the lateral asymmetry of the mouse embryo during early organogenesis.
- The molecular biology of polycystic kidney disease
- Expression of a Delta homologue in prospective neurons in the chick
- New insights into the molecular pathophysiology of polycystic kidney disease.
- Candidate gene associated with a mutation causing recessive polycystic kidney disease in mice.
- Functional correction of renal defects in a mouse model for ARPKD through expression of the cloned wild-type Tg737 cDNA.
- Cell proliferation in mammalian gastrulation: The ventral node and notochord are relatively quiescent
- Critical period of rat development when sidedness of asymmetric body structures is determined.
- Specification of left-right asymmetry in mammals: embryo culture studies of stage of determination and relationships with morphogenesis and growth.
- Epidermal growth factor receptor activity mediates renal cyst formation in polycystic kidney disease.
- Morphogenesis of the murine node and notochordal plate
- Expression pattern of the mouse T gene and its role in mesoderm formation
- The TPR snap helix: a novel protein repeat motif from mitosis to transcription.
- Conserved left–right asymmetry of nodal expression and alterations in murine situs inversus
Cited by
- Cystin, a novel cilia-associated protein, is disrupted in the cpk mouse model of polycystic kidney disease.
- XBX-1 encodes a dynein light intermediate chain required for retrograde intraflagellar transport and cilia assembly in Caenorhabditis elegans.
- Modeling ciliopathies: Primary cilia in development and disease.
- Intraflagellar transport and cilia-dependent renal disease: the ciliary hypothesis of polycystic kidney disease.
- Generation of robust left-right asymmetry in the mouse embryo requires a self-enhancement and lateral-inhibition system.
- TRPP2 channel regulation.
- Left-right patterning from the inside out: widespread evidence for intracellular control.
- Mammalian Clusterin associated protein 1 is an evolutionarily conserved protein required for ciliogenesis
- The Ciliary Baton: Orchestrating Neural Crest Cell Development
- Endothelial Mechanosignaling: Does One Sensor Fit All?
- TRPP channels and polycystins.
- Recent advances in the cell biology of polycystic kidney disease.
- Polycystic kidney disease, cilia, and planar polarity.
- Intraflagellar transport: from molecular characterisation to mechanism.
- Étude des voies de conduction cardiaque : identification des gènes spécifiquement exprimés et impliqués dans des troubles de conduction
- Cilia multifunctional organelles at the center of vertebrate left-right asymmetry.
- Analyse fonctionnelle de la polycystine-1 et de son domaine intracellulaire dans le développement de la polykystose rénale autosomique dominante
- Proceedings of the Eighth International Workshop on Developmental Nephrology: Genes, Morphogenesis, and Function. The Sessions
- A Role for Intraflagellar Transport Proteins in Mitosis: A Dissertation
- Mutation in Tg737 Gene Shortens Neuronal Cilia in Mice
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