Flow-mediated endothelial mechanotransduction.
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Summary
The transmission of hemodynamic forces throughout the endothelium and the mechanotransduction mechanisms that lead to biophysical, biochemical, and gene regulatory responses of endothelial cells to hemodynamic shear stresses are reviewed.
- Type
- review
- Published
- 1995-07-01
- Cited by
- 2,878
- References
- 184
- Access
- Open access
- OpenAlex
- https://openalex.org/W1936770188
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:3167304
Keywords
Mechanotransduction, Hemodynamics, Endothelium, Blood flow, Vascular tone
References
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- Phosphorylation and activation of a high molecular weight form of phospholipase A2 by p42 microtubule-associated protein 2 kinase and protein kinase C.
- Structure and chromosomal localization of the human constitutive endothelial nitric oxide synthase gene.
- Theory and practice of scanning optical microscopy
- Direct stimulation of adenylate cyclase by mechanical forces in S49 mouse lymphoma cells during hyposmotic swelling.
- Activation of phospholipases A2 and C in pig aortic endothelial cells synthesizing prostacyclin.
- The roles of protein C and thrombomodulin in the regulation of blood coagulation.
- The structure and properties of the cell surface coat.
- Tandem scanning reflected-light microscopy of cell-substratum adhesions and stress fibres in Swiss 3T3 cells.
- Nitric oxide: physiology, pathophysiology, and pharmacology.
- Constitutive nitric oxide synthase from cerebellum is reversibly inhibited by nitric oxide formed from L-arginine.
- Stretch-inactivated ion channels coexist with stretch-activated ion channels.
- Spatial and temporal variations of wall shear stress within an end-to-side arterial anastomosis model.
Cited by
- Cytoskeletal Mechanics: List of Contributors
- Enzymatic hydrolysis of luminal coronary glycosidic structures uncovers their role in sensing coronary flow.
- Analyse des mécanismes cellulaires et moléculaires mis en oeuvre dans les vaisseaux sanguins par les composants des fibres élastiques
- Synergistic interaction between endothelium‐derived NO and prostacyclin in pulmonary artery: potential role for K+ATP channels
- Expression of the bumetanide-sensitive Na-K-Cl cotransporter BSC2 is differentially regulated by fluid mechanical and inflammatory cytokine stimuli in vascular endothelium.
- Modulation of Arterial Growth of the Rabbit Carotid Artery Associated with Experimental Elevation of Blood Flow
- Differential regulation of protease activated receptor-1 and tissue plasminogen activator expression by shear stress in vascular smooth muscle cells.
- Dietary salt increases endothelial nitric oxide synthase and TGF-β1 in rat aortic endothelium.
- Evidence for peroxynitrite as a signaling molecule in flow-dependent activation of c-Jun NH2-terminal kinase.
- Pressure-induced upregulation of preproendothelin-1 and endothelin B receptor expression in rabbit jugular vein in situ : implications for vein graft failure?
- Myosin light chain phosphorylation‐dependent modulation of volume‐regulated anion channels in macrovascular endothelium
- Selective modulation of endothelial cell [Ca2+]i response to flow by the onset rate of shear stress.
- Oxidative burst and NO generation as initial response to ischemia in flow-adapted endothelial cells.
- Functional and cellular interactions between nitric oxide and prostacyclin.
- Correlation of intimal hyperplasia development and shear stress distribution at the distal end-side-anastomosis, in vitro study using particle image velocimetry.
- Two‐photon imaging of brain pericytes in vivo using dextran‐conjugated dyes
- Role of tissue kallikrein in response to flow in mouse resistance arteries
- Erythrocyte Signal Transduction Pathways, their Oxygenation Dependence and Functional Significance
- Enhanced external counterpulsation for ischemic heart disease: what's behind the curtain?
- Mechanisms of mechanotransduction.
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